Pyridine C-H Bond Activation And Functionalizatin

In this dissertation, my aim is to study synthesis and catalytic application ofpalladium complexes, including pyridine N-oxide C-H functionalization andenantioselectivity C-C coupling reaction.Transition-metal-catalyzed C-H activation and functionalization of pyridinemoiety was reviewed in Chapter 1. By this way, a series of pyridine derivates wereprepared, which play great roles in pharmaceutical and pesticide.Chapter 2 described that Pd(II)-catalyzed oxidative coupling between pyridineN-oxides and N-substituted indoles via two-fold C-H bond activation has beenachieved using Ag2CO3 as an oxidant. Kinetic Isotope Effect (KIE) indicates that thecleavage of the N-oxide C-H bond is involved in the rate-determining step.In Chapter 3, a series of palladium complexes bearing pincer chairal oxazolineligand were designed and synthesized. In asymmetric Suzuki-Miyaura couplingreaction, these palladium complexes have showed high efficiency andenantioselectivity.