Research On Reaction And Process For Catalytic Dehygrogenation Of Iminodibenzyl To Iminostilbene In Gas-phase

Iminostilbene is kind of important drug intermediates and it is maily used in the production of drugs for nervous disease such as Carbamazepine and Oxcarbazepine. There are manly chemical methods to prepare iminostibene and iminodibenzyl bromination is the gen eral process to produce iminostilbene on industry. Compared with the traditional process to produce iminostilbene, there are many advantages in the process for catalytic dehydrogena-tion of iminodibenzyl to iminostilbene in gas-phase, including shorter technological procee, less by-product and higher quality of product, which make it be very high potential in the industrial application.In the present study, on the basis of the analysis on thermodynamics of catalytic dehy-drogenation of iminodibenzyl to iminostilbene, the stability and life of catalyst and the effect on catalytic behaviour by the dehydrogenation conditions was investigated over potassium promoted iron oxide catalysts used for dehydrogenation in a continuous intergral fixed reactor. The process conditions for catalytic dehydrogenation of iminodibenzyl to iminostilbene were optimized and the best conditions were as follows:temperature be 520-540℃and H2O/IDB be 250mol/mol and WCAT/FIDB be 8gcat·h/gIDB more or less. Furthermore, the macrokinetics of catalytic dehydrogenation of iminodibenzyl to iminostil bene was studied and the Langnmuir-Hinshelwood mechanism model on the basis of doublesites adsorption was established. Meanwhile, the side-reaction mechanism and the source of acridine and 9-methl acridine were determined. These results give important support for further industrial design and optimization of catalytic dehydrogenation of iminodibenzyl to iminostilbene in gas-phase.