| Magnetic nanoparticles prepared in this paper were based on magnetic targeting drug delivery system, two kinds of biodegradable magnetic nanospheres were prepared by two different methods in this paper. By orthogonal experiments, the optimum condition was found. Finally, EPI was loaded on the magnetic nanoparticles.(1)Fe3O4/SA nanoparticles were synthesized by chemical coprecipitation. We have found studied the effects of various factors in the experiment:the amount of sodium alginate and ammomia. At last, we find the optimum condition. Through a series of characterization, we can see that the Fe3O4/SA nanoparticles have small size (about 10nm), good dispersibility. Fe3O4 content of the Fe3O4/SA nanoparticles is 72.18%, saturated magnetization is 68.801emu/g.(2) Fe3O4/CMCNa nanoparticles were synthesized by sonochemical method. We have found studied the effects of various factors in the experiment:pH of the solution, the amount of carboxymethyl cellulose sodium salt, reaction time. At last, we find the optimum condition. Through a series of characterization, we can see that the Fe3O4/CMCNa nanoparticles have small size (about lOnm), good dispersibility. Fe3O4 content of the Fe3O4CMCNa nanoparticles is 76.35%, saturated magnetization is 70.589emu/g.(3) Epirubicin (EPI) was loaded on the magnetic nanoparticles. By TG, the loaded rate of Fe3O4/SA nanoparticles is 10.74%; the loaded rate of Fe3O4/CMCNa nanoparticles is 8.01%. By UV, the loaded rate of Fe3O4/SA nanoparticles is 9.83%; the loaded rate of Fe3O4/CMCNa nanoparticles is 7.87%. By UV, the encapsulation rate of Fe3O4/SA nanoparticles is 88.56%; the encapsulation rate of Fe3O4/CMCNa nanoparticles is 86.58%. The last cumulative release rate of Fe3O4SA nanoparticles can be up to 78.09%; the last cumulative release rate of Fe3O4/CMCNa nanoparticles can be up to 82.03%.Comparing two EPI-loaded magnetic nanoparticles, we can see, Fe3O4/CMCNa nanoparticles have an advantage at drug-loading than Fe3O4/SA nanoparticles. |
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