Preparation Of S-ibuprofen Molecularly Imprinted Membranes And Its Chiral Resolution Performance

Molecularly imprinted membranes (MIM) is a promising technology combined molecular imprinting technology which is of predetermination, selectivity and specificity, with membrane technology which is of stability, continuity and energy saving. MIM have been widely used in the fields of separation, catalysis and sensor. In this paper, by using valuable membrane as support, S-ibuprofen as template molecular,4-vinyl pyridine as functional monomer, S-ibuprofen imprinted membranes were prepared with non-covalent method through surface coating thermal polymerization. The selective binding properties and chiral resolution performance of the membranes were investigated.First, S-ibuprofen molecularly imprinted hollow fiber membrane were prepared and the selective binding properties of that were studied. Non-imprinted membranes didn't have selective binding properties toward S-ibuprofen because of nonspecific adsorption. While imprinted membranes had memorial cavities with high selective recognition, and adsorption selective factor was up to 1.20. Contact angle and SEM characterization explained that there was an dense imprinting layer on the surface of MIM.Moreover, chiral resolution performance of MIM was studied. S-ibuprofen MIMs were prepared by using various flat membranes as support. Permeation experiment showed that R-ibuprofen transfer more quickly than S-ibuprofen through PAN-MIM, which coincide with retarded permeation mechanism, and selective factor was 0.870. while S-ibuprofen transported more quickly than S-ibuprofen through PVDF-MIM and Nonwoven-MIM with facilitated transport mechanism. What's more, S-ibuprofen MIMs were prepared on the surface of PVDF hollow fiber membranes. Permeation experiments of racemic ibuprofen across the membrane imprinted with S-ibuprofen showed that the membrane is enantioselective, diffusion of the template enantiomer being faster than that of its optical antipode. The separation factor was up to 1.16. The permeation mechanism coincide with "facilitated transport" or "facilitated diffusion" model. Specific identification and configuration specificity of MIMs made S-ibuprofen preferentially identified, adsorbed and permeated, and finally achiever chiral resolution.