Pepsinogen And Thymidine Kinase 1 In Early Diagnosis Of Gastric Cancer

Objective: Though analyzing the dynamic expression of serum pepsinogen (PG)Ⅰ,Ⅱand serum thymidine kinase 1 (TK1) in gastric cancer and gastric diseases, to explo-re both value in the early diagnosis of gastric cancer, and to provide clues to early di-agnosis in gastric cancer.Methods:Choosing79 patients with various gastric diseases from the Tianjin port hospital in February 2009～May 2010.These patiens were confirmed by gastroscopy and (or) surgical pathology specimens cytology. Of which gastric cancer in32cases,21 males and 11 females, average age 50.9 years; gastric ulcer in 15 cases,9 males and 6 females, average age 46.6 years; chronic atrophic gastritis in 20 cases,13 males and 7 females, average age of 40.5 years; 12cases of chronic superficial gastritis;7males and 5females, average age 50.2 years; healthy controls in48cases,25males and 23 females , average age 45 years old, had no digestive tract, liver, kidney disease and stomach p-ain history. Detected PGⅠ, PGⅡ, PGⅠ/PGⅡratio and TK1, CEA, CA19-9 level in each group.Results:(1) serum pepsinogen (PG) levels:PGⅠ, PGⅡ, PGⅠ/PGⅡbetween chronic superficial gastritis group and the healthy control group showed no significant differe-nce(P<0.05); PGIand PGⅠ/PGⅡin chronic atrophic gastritis group and gastric cancer were significantly lower than the healthy control group (P<0.01), while PGⅡwas no significant difference (P> 0.05); PGI increased slightly (P<0.05) and PGII was signi-ficantly higher (P<0.01) in gastric ulcer group, while PGI/PGII was no difference(P > 0.05). Serum PGI between chronic atrophic gastritis and gastric cancer were no si-gnificant differences (P>0.05), but there were significant difference among gastric ca-ncer, superficial gastritis and gastric ulcer group (P<0.01); serum PGⅡamong atrop-hic gastritis group, gastric cancer group, and superficial gastritis group were no sig-nificant difference (P>0.05), they associated with gastric ulcer group had significant difference (P<0.01); PGI/PGII in superficial gastritis group and gastric ulcers group no significant difference (P>0.05), they associated with gastric cancer and atrophic gastritis had significant difference (P<0.01). (2) Serum tumor markers carcinoembr- Yonic antigen (CEA) and carbohydrate antigen (CA19-9) levels:CEA and CA19-9 in gastric cancer group were significantly increased, compared with the control group th-ere were significant difference (P<0.05); and other groups in both content and health control group showed no significant difference (P>0.05).Serum CEA, CA19-9 betwe-en gastric cancer group and other groups had significant differences (P<0.05), while the other benign gastric diseases were no significant differences (P> 0.05). (3) Serum thymidine kinase 1 (TK1) levels:serumTKl of the experimental group concentrations significant difference (P<0.01); TK1 in gastric cancer group was significantly higher than benign gastric disease group (P<0.01), benign gastric disease group compared wi-th the control group no sigificant difference (P>0.05);TK1 in no treatment group and no significant effect group were significantly higher than the significant effect group (P<0.01).Conclusion:The serum pepsinogen level dynamically reflects the gastric mucosa state,and it is of great significance in gastric disease identification and early diagnosis of gastric cancer. Thymidine kinase 1 in gastric cancer diagnosis, disease monitoring, prognosis and other aspects of the digestive tract may be superior to other tumor mar-kers, and has better clinical significance.