Study On The Relationship Between Obesity, Sex Hormone Levels And Insulin Resistance Among 6-18 Years Old Children And Adolescents

Objectives:To explore the relationship between obesity, sex hormone levels and insulin resistance among 6-18 years old children and adolescents, and the influential factors of insulin resistance.Methods:A cross-sectional study with 207 children and adolescents was carried out. Select the target population from peoples who came to dental hospital of Tian Jin medical university to check health. Information was collected through interview using questionnaire. T, E2, FINS was detected by radioimmunoassay(RIA). T test and non-parametric statistical test was used to analyze the difference between the normal group and the overweight and obese group. Rank correlation test was used to analyze the relationship between obesity, sex hormone levels and insulin resistance. Unconditional multivariate logistic regression model was used to analyze the influential factor of insulin resistance.Results:1. The relationship between obesity and sex hormonesT of the normal group is lower than the overweight and obese group among prepubertal boys and girls (P<0.01), and there is no difference in E2 between two groups (P>0.05). There was no difference in T and E2 among adolescents (P>0.05).T and E2 was significantly associated with increased BMI among prepubertal boys (P<0.05); T level was significantly associated with increased BMI among prepubertal girls (P＜0.001), but not E2 (P>0.05). There was no relationship between T, E2 and BMI among adolescents (P>0.05).2. The relationship between obesity and insulin resistanceIRI, ISI of the normal group was higher than the overweight and obese group (P<0.05), and ISI was oppsite (P<0.05) among prepubertal boys and girls and adolescents, but there was no difference in FBG between two groups (P>0.05).BMI was significantly associated with increased INS, IRI and decreased ISI (P＜0.001), but not with FBG (P>0.05) among prepubertal and adolescent boys. BMI was significantly associated with increased INS (P<0.05), but not with FBG, IRI, ISI among prepubertal and adolescent girls (P>0.05).3. The relationship between sex hormone and insulin resistance T was significantly associated with increased INS, IRI and decreased ISI (P<0.01), but not with FBG (P>0.05) among boys of normal group; There was no relationship between E2 and FBG, INS, IRI, ISI (P>0.05).T was significantly associated with increased INS, IRI and decreased ISI (P<0.01), but not with FBG (P>0.05) among boys of overweight and obese group; E2 was significantly associated with increased FBG, INS, IRI (P<0.05) and decreased ISI(P＜0.01).T and E2 significantly associated with increased INS, IRI and decreased ISI (P<0.05), but not with FBG (P>0.05) among girls of normal group.T was significantly associated with increased INS, IRI and decreased ISI (P<0.05), but not with FBG (P>0.05) among girls of overweight and obese group; There was no relationship between E2 and FBG, INS, IRI, ISI (P>0.05).4. The influential factor of insulin resistanceResults from univariate unconditional logistic regression analysis showed that The influential factors of insulin resistance were BMI, puberty, E2, WHtR, TG, father's occupation, fruit and HDL, OR was 1.794(1.210～2.660),2.603(1.365～4.967), 1.023(1.008～1.038),1.096(1.032～1.164),6.357(2.270～17.799).0.657(0.431～1.002), 0.742(0.560～0.985),0.493(0.214～1.136).The results of multivariate conditional logistic analysis showed that the influential factors of insulin resistance were BMI, puberty, E2. WHtR, TG and HDL.Conclusion:The level of insulin resistance of the overweight and obese group was higher than the normal group among children and adolescents, and the insulin sensitivity was opposite. T was significantly associated with insulin resistance among boys and E2 was significantly associated with insulin resistance among girls of the normal group. E2 was significantly associated with insulin resistance among boys of overweight and obese group and T was significantly associated with insulin resistance among girls. The influential factors of insulin resistance were puberty, WHtR, TG, HDL.