The Clinical Study On Effect Of Acupuncture On Serum S-100B Protein And Neurological Deficit In The Patients Of Acute Cerebral Infarction

Objective:To observe the effects of acupuncture on the level of S-100B protein in patients with acute cerebral infarction and neurological deficit scores, as well as the impact of acupuncture on acute cerebral infarction and its mechanism to clinical application.Method:Forty patients were randomly divided into the control group and the treatment group with twenty patients in each one. All data was collected from the administration in hospital at day 1, day 4 and day 14 after the fasting blood drawn 1 time. The S-100B levels were tested from the hospital laboratory through the U.S. National Institutes of Health Stroke Scale (NIHSS) For neurological deficit scores at the same time. All the treatment groups were started of acupuncture treatment at the first day with NO.30mm needles through reinforcing-reducing techniques. Each hole was all acupunctured at the level of requirement. The treatment was conducted once daily with 6 times as a period and observed in 2 weeks. There is no significant finding with P>0.05 in terms of age, gender, concomitant disease score, past history score, degree of neurological deficit between two groups. All patients were given relatively same level of observation of conventional western medicine.Result:(1) The result from the control group on the first day compared with that from forth day was not statistically significant (P> 0.05) at NIHSS score. However between the first day and the fourteenth day, the difference was significant (P<0.05), and the forth day and the fourteenth day, the difference was significant (P<0.05).(2) The result from the treatment group on the first day compared with that from forth day was not significant (P> 0.05) at NIHSS score. However between the first day and the fourteenth day, the difference was significant (P<0.05), and the forth day and the fourteenth day, the difference was significant (P<0.05).(3) The results of two groups from the first day and the forth day, NIHSS score differences were not significant (P> 0.05). But the result from the first day compared with that from the fourteenth day was statistically significant (P<0.05).(4) The results of the control groups from the first day, the forth day and the fourteenth day, serum S-100B protein differences were significant (P<0.05). The results of the treatment groups from the first day, the forth day and the fourteenth day, serum S-100B protein differences were significant (P<0.05).(5) The results of two groups from the forth day and the fourteenth day, serum S-100B protein differences were not significant (P> 0.05).(6) NIHSS score and serum S-100B protein levels were not significantly correlated. Conclusion:(1) Both the control group and the treatment group in patients with acute cerebral infarction have the improved NIHSS scores. However, the more significant effect on the treatment group was observed.(2) The serum S-100B protein level was changed in a dynamic way in patients with acute cerebral infarction. After the onset of infarction, the serum S-100B protein level was increased dramatically and then reached a peak point before gradually decreased and the treatment group had a faster decline compared with the other one,the levels of serum S-100B protein were decreased in the two groups,but there was no significant finding on the level of S-100B protein from the treatment group.(3) NIHSS score and serum S-100B protein levels were not significantly correlated.