Changes And Clinical Significance Of Serum IL-6,TNFα,S-100b In Patients With Acut Cerebal Infarcts

Abstrct:Objective:To analyze the changes and clinical significance of IL-6,TNFα, S-100b.and to explore their pathologic mechanism in the brain ischemia.Methods:58 patients consecutively admittied with first-ever ischemic cerebral infarction within the first 24 hours from onset were included,and 30 healthy subjects were selected as controls.The serum level of IL-6,TNFαand S-100b was measured by enzyme linked immunosorbent assay.All the paitents that experienced stroke were observed on the 1st,3rd,7th day,the severity of stroke was scored at the same time using the NIH stroke Scale(NIHSS).The subsequent volume of brain lesion as a consequence of stroke was measured by CT or MRI within 48-72h after the onset.Results:1.Both the serum levels of IL-6,TNFαand S-100b were significantly higher in patients within the first day after the onset than those of the contros.IL-6,TNFa attain the peaks within 24 hours after the attact,athough the S-100 peak was arrived on the 3rd day.They all decreased gradually after the peaks.2.There was a positive correlation between both the peak levels of IL-6,TNFαand S-100b and the infarct volume and NIHSS..3.Higher levels of IL-6,TNFαand S-100b in serum inpatients with neurological deterioration compared with paitents who retained clinically stable or improved course.Conclusion:The serum levels of IL-6,TNFαand S-100b were upregulated,which may take part in the pathogenesis of acute cerebal infarction by deferent parthway.The levels of IL-6,TNFαand S-100b may reflect both the degree of pathologic lesion and the infarct volum.They may be markes for outcome in acute ischemic stroke.