Research Of TCM Syndrom Differentiation Of Carotid Artery Atherosclerosis

Background:Cardiocerebrovascular disease is harmful to human health. It is no doubt that artery atherosclerosis is the most important factor to cause cardiocerebrovascular disease. Carotid artery is always the place atherosclerosis tend to concentrate. Also the place of carotid artery is shallow, it often as a window to observe the whole atherosclerosis of the body. Carotid artery atherosclerosis has close relationship with cardiocerebrovascular disease. So it has very important clinical significance to research and analysis the reason carotid artery atherosclerosis plaque to take place and method to treat this disease. Modern medicine has found some prevention ways from the view of pathophysiology. Though, the drugs and advanced operation methods that the modern medicine use have many side effects and risks. These limit the clinic treatment. Traditional medicine treat carotid artery atherosclerosis by TCM syndrome differentiation under the guidance of holistic approach. This has certain characteristic and advantage, it also reduce the influence take by adverse actions. But, at present, the TCM syndrome differentiation of carotid artery atherosclerosis are variety and specific because of different views the TCM clinical researchers took to consider this question which against the targeted therapy. Therefore, it is necessary to perfect the system of TCM syndrome differentiation of carotid artery atherosclerosis.Objective:To analysis and research the TCM diagnostic informations of carotid artery atherosclerosis to extract and determine the syndromes of carotid artery atherosclerosis. Explore combination rules of disease and syndromes of carotid artery atherosclerosis, to provide certain evidence for the study on standardization of carotid artery atherosclerosis syndrome differentiation.Methods:Using epidemiological and questionnaire survey methods collect clinical data on 350 cases of carotid artery atherosclerosis syndrome. Combined with the theory of TCM to syndrome differentiation by professor with high qualification for clinical experience of TCM syndrome, the data will be entered into the computer by Epidata3.1. Then we will establish the database. Use the SAS9.1 and MPLUS software and factor analysis methods to process and analysis the data. Draw carotid artery atherosclerosis syndromes distribution characteristics. Based on this, we extract the TCM factors of carotid artery atherosclerosis, and define the corresponding relationships between the syndrome types and symptoms.Results:350 patients of carotid atherosclerosis may dialectical classification for four kinds: Excessive of liver fire, Yin deficiency of liver and kidney, Insufficiency of renal Qi, Retention of turbid phlegm and blood stasis. The corresponding symptoms of each syndrome type are as follows. Excessive of liver fire:flushing, hot eyes, dark urine, headache, fullness of head, bitter taste, restlessness, irritable, constipation, dry mouth, poor eyesight, red tongue, yellow coating, taut pulse; Yin deficiency of liver and kidney:a hot sensation in the palms and soles, night sweat, dry mouth and throat, hypochondriac pain, soreness and weakness in the lower back and knees, swimming, a dry and unsmooth sensation in the eyes, tinnitus, lack of sleep, a poor memory, dreaminess, irritable, restlessness, red tongue, a thin coating, yellow coating, rapid pulse. Insufficiency of renal Qi:clear abundant urine, a poor memory, tinnitus, soreness and weakness in the lower back and knees, greasy coating, yellow coating; Retention of turbid phlegm and blood stasis:poor appetite, vomiting of phlegm, a tongue with ecchymosis, a sticky feeling in the mouth, obesity, dizzy, a pale tongue, enlarged tongue, surging pulse. The related coefficient of Yin deficiency of liver and kidney and Insufficiency of renal Qi in relations is 0.2. There is possibility that these two syndrome types exist mutual and clip. The elated coefficient of other syndrome types are negative, illustrate little possibility that there exist mutual and clip among other syndrome types.Conclusion:1. The method of factor analysis can divided carotid atherosclerosis into four syndrome types: Excessive of liver fire, Yin deficiency of liver and kidney, Insufficiency of renal Qi, Retention of turbid phlegm and blood stasis.2. Factor analysis is effective data analysis method to explore TCM syndrome differentiations.