Correlation Between ALDH2 Polymorphism And Coronary Slow-flow Phenomenon In Shandong Han People

ObjectiveTo explore the correlation between ALDH2 (G487A) polymorphism and coronary slow-flow phenomenon in Shandong han people.MethodsA case-control study method was adopted.625 Han patients during the period from January 2006 to July 2009 who were suspected of coronary atherosclerotic disease because of chest pain and chest oppression in emergency department of qilu hospital of Shandong university were enrolled in the study,and 59 of them were targeted as research object without finding Obvious lesions in Coronary angiography.And they were divided into the coronary slow folw group(36 cases)and control group(23 cases)according to the TIMI frame count(TFC).The clinical base-line data were collected using a structured questionnaire containing the subjects' clinical characteristics,including age, gender, body mass index(BMI),hypertension,diabetes,smoking.drinking,family history of coronary artery disease(CAD)and lipid items,et al.The TIMI frame count(TFC) of all object were determined by two seasoned interventional radiologists,including LAD (Left Anterior Descending Branch),LCX(Left Circumflex Branch),RCA (Right Coronary Artery)。According to Gibson studies, that the blood flow velocity of either a coronary artery is greater than the normal two standard deviation [LAD (36.2±2.6), LCX (22.2±4.1), RCA (20.4±3.0)] will be defined as the coronary slow flow phenomenon (CSFP).Statistical analysis were performed by SPSS software 13.0, analyse the clinical baseline datas ALDH2 gene polymorphism and TFC between the two groups, using multiple regression analysis Logistic to balance confounding factors, calculate odds ratio (Odds Ratio OR) and 95% confidence interval (95% Confidence Interval CI).Result1. The gender, BMI, smoking history, drinking history, family history of coronary artery disease, diabetes, hypertension and lipid levels make no significant differences between the two groups,and the age level of CSFP group is lower than control group (P>0.05)2. The TFC of the three vessels (LAD,LCX,RCA) were significantly higher in CSFP group than in control group(P<0.001).3. A total of 16 gene mutation in CSFP group, but in control group there were 4 cases of gene mutation. The genotype mutation rate in CSFP group wss 44.44%, and 17.40% in control group。The genetype mutation rate in CSFP group was significantly higher than the control group(X2=4.584 P=0.032).4. We take ALDH2 genotype, age, smoking, drinking, diabetes, hypertension and family history of coronary artery disease as the independent variable, whether or not slow blood flow as the dependent variable. That was found that ALDH2 gene mutation is an independent risk factor of CSFP after Logistic regression analysis(OR= 2.322,95% CI 1.084-4.974, P=0.021).5. During the six-month follow-up period,5 case of the CSFP group were hospitalized because of angina pectoris,and none in the control group.Conclusion1. The CSFP may be more likely to occur in the patients with ALDH2 gene mutation.2. The CSFP is more common in younger patients.