Expression Of LI-cadherin And CDX-2 In Serum Of Patients With Gastric Cancer And Their Significances

Objective:To evaluate the clinical significance and expression of serum Li-cadherin/CDX-2 and tissue Li-cadherin/CDX-2 in gastric cancer, and provide some experimental basis and theoretical basis for the two as a new tumor marker in aspects of diagnosis and treatment of gastric cancer.Methods:Serum levels of LI-cadherin/CDX-2 were measured with enzyme-linked immunosorbent assay (ELISA) in 48 patients with gastric cancer and 29 controls. At the same time semi-quantitative immunohistochemistry were used to detcet the expression of LI-cadherin/CDX-2 in tissue and compared with the serum concentration.Results:Both the gastric cancer patients and normal control can be detected the expression of LI-cadherin/CDX-2. The serum levels of LI-cadherin in gastric cancer were significantly higher than those in the controls (P<0.001/P<0.001); LI-cadherin expression was significantly correlated with differentiation (P<0.001), Lauren's classification (P<0.01); and CDX-2 expression was significantly correlated with Lauren's classification (P<0.05),differentiation (P<0.05), lymph node metastasis and clinical stage (P<0.001); both serum levels of LI-cadherin and CDX-2 are closely related with its expression in tissue (P<0.05); serum levels of LI-cadherin are closely related with serum levels of CDX-2(P<0.001); after surgery and chemotherapy, there is no significant change in the serum levels of LI-cadherin/CDX-2(P>0.05).Conclusion:The serum levels of LI-cadherin depends on tumor differentiation and cell type, high level of serum LI-cadherin suggests a better differentiation of tumor cells, while the level of serum LI-cadherin in intestinal type gastric cancer were higher than diffuse gastric cancer; the serum levels of CDX-2 was significantly correlated with differentiation, lymph node metastasis, cell type; the serum levels of CDX-2 in well-differentiated tumor cells and intestinal-type gastric were higher than poorly differentiated tumor cells and diffuse gastric cancer, while its expression level was inversely associated with lymph node metastasis, high level of serum CDX-2 indicates a low invasive ability of gastric cancer; serum levels of LI-cadherin/CDX-2 and its expression in tissue was positively correlated, both may reflect its expression in gastric cancer; clinical treatment can not change the serum levels of LI-cadherin/CDX-2, for an unknown reason.