The Compound Kanggan Piece Pharmaceutical Research

Purpose:The compound prescription anti-feeling inoculation fluid originally the preparation room variety which uses widely in the late 80s for the Liaoning Chinese medicine university affiliated hospital, has the refrigeration to alleviate heat-producing factors, the disintoxicating, antibacterial, functions and so on anti-virus, the main application and the virulent cold, have the good clinical curative effect. This topic uses modern the research technique, makes the compound prescription anti-feeling piece the compound prescription anti-feeling inoculation fluid, is for the purpose of promoting the curative effect to be accurate, the biological exploitability high, the poisonous side effect small, takes the convenience the modern compound prescription anti-feeling preparation.Material and method:1. The preparation craft through the orthogonal design experiment, respectively take the volatile oil total.quantity, the volatility oil pocket gathers the material quantity, the volatility oil pocket and rate, the table considers the Yichun content as the determination target, the optimal volatile oil extraction process, Beta-the link dextrin package and the craft and the water extraction process condition, determines the compound prescription anti-feeling piece finally the best preparation craft.2. Quality specification research used the thin layer chromatography to the dandelion, the weeping forsythia to carry on the qualitative distinction; Uses the highly effective liquid phase chromatography, considers Yichun take the table as the target, has carried on the content determination, has established the compound prescription anti-feeling piece quality specification.3. Pharmacodynamics preliminary study Gathers the butcher virus through the respiratory tract (RSV) to organize half of infection quantities in the Hela cell the determination, the toxic determination and the medicine gathers the butcher virus to the respiratory tract the inhibitory action, the appraisal compound prescription anti-feeling piece gathers the butcher virus in vitro to the respiratory tract the function.Results:1. Optimal leaves the volatile oil extraction best craft, the volatility oil pocket and the best craft and the water extraction best craft, has formulated the compound prescription anti-feeling piece preparation craft.2. The determined that the reasonable feasible multi objective quality control method, has established the compound prescription anti-feeling piece quality specification.3. The compound prescription anti-feeling piece gathers the butcher virus to the respiratory tract (RSV) to have the obvious inhibitory action, assumes the obvious quantity effect relations, indicated that the compound prescription anti-feeling piece has suppresses RSV the pharmacological action.Conclusion:1. The compound prescription anti-feeling piece's preparation craft reasonable, scientific,stable and practical.2. The compound prescription anti-feeling piece quality specification advanced practical, guaranteed that this medicine quality is controllable.3. The compound prescription anti-feeling piece has the refrigeration, to alleviate heat-producing factors, the disintoxicating, antibacterial, functions and so on anti-virus.4. The development curative effect is accurate, the quality controllable anti-flu new medicine has provided the scientific basis, simultaneously has established the theory and the experiment foundation.