| Part I:Study the precise location and the language lateralization of the functional language area related with the semantic or syntactic paradigm on functional MRIPurpose: To investigate the location of functional language areas on normal volunteers on functional magnetic resonance imaging (fMRI), and analyze the effect of semantic or syntactic associated to the functional language areas in brain on bold oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI). And to obtain a relatively stable and suitable language tasks for clinical application on functional magnetic resonance imaging. To explore to the role of the language functional areas in the language product and the relationship between the language functional areas through analyzing the result of semantics and syntax tasks.Materials and methods: 16 healthy volunteers participated in the study, 9 males and 7 females, range 25-62 years. The mean age was 38.6 years. All of them were native Chinese language speakers and found no aphasia, normal or corrected to normal vision and no history of neurological or psychiatric disorder. They were all right-handed according to《Chinese aphasia check list》. All completed the semantic or syntactic judging task. Imaging was performed on a 3.0-T Scanner with a standard headcoil. A 3D-FSPGR sequence was applied to obtain high-resolution anatomical images before the functional image acquisition. Functional data were collected with agradient-echo, echo planar imaging (EPI) sequence. And to applicate of brain-wave realtime (RT) to collected fMRI images and monitored the stimuli of the whole brain imaging. A fMRI block-design was employed, supplemented by the event-related stimulation pattern. All the volunteers executived the judgment of semantic or syntax tasks while the fMRI scaning. And the stimulus content and control content were showed altermated and lasting for 20 seconds respectively. Each condition consisted of seven blocks. In between the blocks, it was consisted of a flashing icon. The functional imaging was analyzed using SPM8. For each run, slice timing, motion correction, spatial normalization, spatial smooth processing were done. Second-level analyses were performed by estimating the voxel vise t-statistic for semantic and syntax condition using standard hemodynamic response function model. At last, locationed and analyzed the functional language areas in brain on bold oxygen level dependent functional magnetic resonance imaging of semantic or syntactic associated tasks. And to obtain a relatively stable and suitable language tasks for clinical application on functional magnetic resonance imaging.Results: 26 times of semantic tasks and 21 times of syntax tasks were recruited after affected factors (head motion). Activated regions in semantic task include bilateral inferior frontal gyrus, bilateral medial frontal gyrus, left middle frontal gyrus, bilateral angular gyrus, left posterior inferior temporal gyrus, cingulate gyrus.. Activated regions in synax task include right inferior frontal gyrus, bilateral Medial frontal gyrus, bilateral middle frontal gyrus, bilateral angular gyrus, cingulate gyrus. Record the number of pixels of the brain activation and intensity values, calculate the area of the brain activation lateralization index (LI), Semantic task activated brain areas associated with the synax task activation area had a large overlap, Brain regions activated in both tasks included right inferior frontal gyrus, bilateral angular gyrus, and cingulate gyrus. volunteers meeting the requirements showed the left hemisphere advantage in the semantic tasks, while showed right hemisphere advantage in the synax tasks.Conclusion: the language generation mechanism is complexity, which involves multiple brain areas, while the semantic or syntax task related to more complexity and advanced cognitive brain activites. Using the judgment of semantic or synax task were effective tasks for detecting brain areas related to expressive language and neural network with functional MRI. Study the precise location and the language lateralization of the functional language area related on preoperative functional MRI in patients with brain tumorObjective: To observe the location and the language lateralization of the functional language areas in patients with brain tumors, and to found whether there is the same in the location and lateralization compared with the normal volunteers. Evaluated the relationship between the location and the language lateralization of functional language areas with the lesion in the brain, and analyzed the causes of this phenomenon.Materials and methods: 11 patients participated in the study (8 cases of glioma, 1 case of gliosarcoma, 1 case of brain metastases, 1 case meningioma, all lesions were located in or around the left frontal lobe or frontotemporal lobe, or the edema involved the frontal lobe), 6 males and 5 females, range 27-61 years. The mean age was 41.25 years. All of them were native Chinese language speakers and found no aphasia, normal or corrected to normal vision and no history of neurological or psychiatric disorder. They were all right-handed according to《Chinese aphasia check list》. All completed the semantic or syntactic judging task. High-resolution anatomical images and functional data were performed. All the raw data were analyzed using the SPM8. At last, to located and analyzed the functional language areas in brain of patients. Compared with the normal functional language areas, observed the change and record the number of pixels of the activation area and calculated the lateralization index.Results: 17 times of semantic tasks and 16 times of syntax tasks were recruited after affected factors (head motion). Six of eleven patients were asked to complete all the four sessions. It was fount that the location of functional language area located adjacent of the lesion. In other lobes, the functional area was similarly with the normal volunteers. And all of 8 were showed right hemisphere activation. The LI was less than 0.10.Conclusion: In pathological condition, the infiltration growth of the brain lesion could cause the reorganization of brain structure, led to functional areas reorganization and compensation by contralateral brain regions or adjacent brain lesions without damage. Although the language process in the brain has significantly lateralization, which wound change in this case. So the localization of functional areas was important for clinical surgery of perfectly excision of lesion. |
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