Pharmacotherapy For Patients With Schizophrenia: Analysis Of Outpatients And Inpatients

Objective:To investigate the clinical utilization of drugs for outpatients and inpatients with schizophrenia , so as to further regulate the rationality of our treatment method and improve therapeutic effect, as well as reduce adverse reactions.Materials and methods:1. Using the self-designed questionnaire to investigate the patients who went to our hospital for the first. time.2. The outpatients and inpatients were analyzed with regard to DDDs , drug utilization index(DUI) and drug combination by using the defined daily dose (DDD) ,which were recommended by WHO Collaborating Center for Drug Statistic Methodology.3. Data analysis: Data were presented as mean±?standard deviation ( x±S), and statistically analyzed by two independent samples t test with EXCEL 2003 and SPSS13.0, when normally distributed. Otherwise,nonparametric test wsa applied when two sets of data for the measurement data,using the Chi-square analysis. A level of P≤0.05 was accepted as statistically significant.Results :1.There were 72.6% of outpatients with schizophrenia used single kind of antipsychotic drugs , the most common drug used was Olanzapine ;53.4% of inpatients with schizophrenia used single kind of antipsychotic drugs ,the most common drug used was Risperidone . Comparison of single drug effects, in-patient group was better than out-group.2.The survey was 38.3% in the combined treatment, including out-patient group was 27.4% and in-patient group was 46.6%. The most combination of out-patient group was Olanzapine with Risperidone,while of in-patient group was Clozapine whit Risperidone.3. The survey results show that a single drug and combination therapy had no statistically significant effect.4.The DUI of outpatients were all greater or equal to 1;while the DUI of most inpatients were greater or equal to 1,except Aripiprazole,Olanzapine and Loxapine.5.There were 66.2% of outpatients used anticholinergic drugs which were 67.06% of inpatients. There were 18.04% outpatients who had been taken benzodiazepine for longer than 4 weeks, which were 13.35% of inpatients.Conclusions:The psychopharmacotherapies in our hospital were almost rational, but some improper phenomenon still existed.