The Research On The Relationship Between Moxisbution Volume And Effectiveness In Hyperlipemia Rats Treated By The Warming Moxibustion

Objective:To observe the different effects among different doses of warming-moxibustion for acute hyperlipemia rats on levels of blood lipid,local temperature,variation of the local tissues and the dose-effect relationship.Methods:72 adult male, Sprague-Dawley rats were randomly divided into 6 groups:blank control group, hyperlipemia model group, lovastatin intragastric administration group, warming-moxibustion for 5min group, warming-moxibustion for 10min group, and warming-moxibustion for 15min group,with 12 in each group. Except blank control group,mise in other 5 groups were Intraperitoneal injecting 75% yolk galact to estsblish acute hyperlipemia models,and given propotional therapies or nothing cute on the same day. We use chromatography method to test the serum cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high density lipoprotein(HDL) after 3 times of therapies. Acupoint temperatures of three common different quantities of ginger-separated moxibustion (5min,10min,15min) were measured respectively in HLP rats,and then a comparison of surface temperature changes in two acupoints was made among pre-moxibustion,moxibustion-processing and post-moxibustion; Estimate the local tissues by using HE staining method.Results:1.â‘ Different dose of warming moxibustion treatments all had effects on decreasing serum TC,TG,LDL-c,warming moxibustion 10min group and 15min group on increasing HDL-c.â‘¡Comparison the effects among tree different dose of warming moxibustion on regulating TC,LDL-c is no significance.â‘¢Moxibustion lOmin group have the best effects on decreasing ondecreasing TG level.â‘£A significant increace in HDL occurred on moxibustion 10 min and 15min group,and it seemed like that 10min group is better in increasing HDL; 2.The maximal surface temperatures of Shenque and Zusanli among three different quantities of warming moxibustion were different. The discrepancy showed statistical significance; 3.When warming moxibustion completed,the discrepancy of temperature of Shenque with different moxibustion quantities showed statistical significance,but Zusanli did not.Conclusion:waming-moxibustion is effective to regulate the abnormal levels of blood lipid, but the effects were different by using different time on different indexs; Stimulation of different quantities of moxibustion is an important factor affecting acupoint local temperature,while the thermal effect of warming moxibustion in different acupionts shows a discrepancy.;With the increase of the quantities of the waming-moxibustion,the damage of the local tissues was more effective and regular for collagen protein from epidermis.