Clinical Epidemiologic Study Of TCM Syndromes Of Advanced Primary Liver Cancer

Objective:Primary Liver Cancer (PLC) is a kind of disease that would present a serial of different syndromes during its development and combined with excess types and deficiency types. Though the life span of liver cancer have already be extended along with the development of "Treating Preventable Disease" and medical treatment, such as Targeted Therapy, the death rate of liver cancer is still in the third place in China. Syndrome differentiation and treatment is the characteristics and advantages of Chinese Traditional Medicine (TCM), and provides patients with the most appropriate individualized treatment program. For the primary clinical studies in syndromes of liver cancer, they carried with larger samples, but lack of statistical analysis that combined with bio-markers, such as Alpha-fetoprotein (AFP), and other bio-markers of liver cancer. This research that recognizes the syndromes distribution of advanced primary liver cancer with standardized syndromes and bio-markers.Methods:A clinical epidemiologic study was carried out, which based on TCM four diagnostic methods and laboratory reports.138 cases were examined in 2 TCM hospitals from December 2006 to June 2010. All data input was carried out and completed with SPSS 10.0 software.Result:According to the study, the proportion of 5 syndrome distribution types:spleen deficiency type (65cases,47.1%), dampness-heat type (45cases,32.6%), Qi stagnation type (17cases,12.3%), blood stasis type (6cases,4.4%), Yin deficiency type (5case,3.6%).63.0% of PLC patient with Hepatitis B virus (HBV) infection, but there is no statistical significant in 5 syndrome distribution types between HBV inflection and non-HBV infection patients (x 2=14.12, v=16, P=0.59, P>0.05). Among the bio-markers, the P-value (x2=10.58, v=4, P=0.03, P<0.05) of GGT relate to 5 syndrome distribution types indicates that most of patient with GGT>50. There is no statistical significant in 5 syndrome distribution types between hepatocellular carcinoma and cholangiocelluar carcinoma (x2=8.32, v=12, P=0.76, P>0.05), nor as the different types of liver cancer pathology. Conclusion:The result showed the syndromes of advanced primary liver caner patients mainly are spleen deficiency type and dampness-heat type, and can be considered as a choosing to TCM treatment. The hepatocellular carcinoma is mostly appeared in the study, and most of PLC patient with HBV infection. Consequence to the other PLC epidemiologic researching, it indicates that Hepatitis B virus plays an extremely important role to PLC. The GGT number of most PLC patients that with spleen deficiency type and dampness-heat type is larger than 50U/L.