Study On Synthesis Of Honokiol

Honokiol is a traditional Chinese herbal medicines of the main active component of Magnolia officinalis, the current research is focused on its pharmacological aspects, cultivation techniques and methods of extraction. Honokiol with the elimination of chest stuffiness, stomach, stop pain, lower gas Jiangni, lower cholesterol, cough, anti-aging, anti-allergy, blood circulation and so on. In recent years, with the continuous development of medicine, the pharmacological effects of honokiol more square pan, studies have shown that honokiol also has anti-inflammatory, antibacterial, antioxidant, anti-tumor, inhibition of morphine withdrawal reactions. In addition honokiol now open to new uses mental diseases, as well as the potential aspects of inhibition of cancer cells.Honokiol market more expensive, usually extracted from Chinese herbal medicines Magnolia, separation and purification are. Way to get through the synthesis of honokiol, magnolol will benefit the protection of rare medicinal herbs, protecting the ecological environment, but also a lot of meet market needs. On the synthesis of honokiol few studies, and steps more, and the yield is not high. Therefore, we propose a synthetic route, minutes to complete the five-step synthesis, the yield has increased.In this paper,4-allyl methyl ether and 4-bromo anisole as the starting material synthesis and honokiol. The results show that the 4-Preparation of allyl methyl ether 2-bromo-4-allyl anisole optimum conditions for the reaction temperature at room temperature, reaction time 2 h, Pyridine bromide:4-bromo anisole 1:1, yield 65%; from 4-bromo anisole Preparation of 4-bromo-2-allyl anisole optimum conditions for the reaction temperature 40℃, reaction time 5 h,4-bromo-benzoyl ether with allyl bromide in the molar ratio of 1:1, the yield was 80%; the 4-bromo-2-Preparation of allyl methyl ether into the corresponding Grignard reagent reaction conditions suitable for the 4-bromo-2-allyl anisole with Mg the molar ratio of 1:1, reaction time 3 h; 2-bromo-4-allyl anisole with 4-bromo-2-allyl Preparation and honokiol anisole reaction conditions suitable for the use of catalyst NiCl2(PPh3)2, reaction time 12 h, the prepared honokiol ether placed in 50 ml toluene, by adding excess Nal, heating, demethylation, by honokiol, two steps total yield 60%; synthesis of honokiol in the total yield 31.2%.'HNMR analysis of graph identified honokiol.