The Comparison Of The Efficacy Of The Catheter Directed And Systemic Therapy For The Lower-Extremity Deep Vein Thrombosis

Objective:To observe the clinical outcome and follow-up consequence of deep venous thrombosis of lower extremities underwent local catheter-directed thrombolysis and systemic thrombolysis and to evaluate the efficacy of these two therapiesMethods:Eighty patients with deep venous thrombosis comprise local catheter-directed thrombolysis group (38 cases) and systemic thrombolysis group (42 cases), local catheter-directed thrombolysis was performed by placing the thrombolysis catheter directly into the venous thrombus followed by continuous urokinase administration to lyse the thrombus through Micro-injection pump. Urokinase was adminisdered through peripheral veins among systemic thrombolysis group, thrombolysis drugs (mainly limb dorsal foot vein) injection of urokinase. The rating of venous patency, the rate of improved venous patency and the difference between the circumference of healthy and affected limbs were used for evaluating the efficacy of the two treatments. All of the patients were discharged six months after treatment and subject ot the follow-up visit.Results:Among these patients there was no significant difference in the circumference of the thigh and shank limbs at both sides (P<0.01). The difference in the circumference of the upper and lower limbs at both sides and their patency rate were shown to be significant within each group (P<0.01) and between the two groups (P<0.01) at different time points after treatment. The difference in the circumference of the thigh and shank at both sides and their patency rate were found to be significant (P<0.01) at the end of the 6 month follow-up period. Meanwhile, no significant difference was detected in the above parameters between the groups ((P>0.05).Conclusion:In terms of the short-term outcome local catheter-directed thrombolysis is surprior to systemic thrombolysis in the treatment of acute deep venous thrombosis of lower extremities. However, No significant difference was detected in the long-term outcome brought about by the two therapies.