| Object:1. Using event-related potential research language cognitive function of patients with aphasia after brain injury, discover the Chinese cognitive processes in brain.2. Investigating the clinical value of event-related potentials assess language function in patients with aphasia.Methods:15 patients with aphasia whose language dysfunction after traumatic brain injury were selected as a single lesion and 15 cases whose language function was normal after traumatic brain injury were selected as case-control group patients and 15 healthy subjects as normal control group, They received MMSEand P300,ABC and N400 experiments.N400 experiments were based on primes which were divided into "pictures-the words" and "sentence-the words" two parts, each part according to the target words of different parts of speech are divided into verbs and nouns. Using Neuroscan 40-channel evoked potential record of subjects F3, FZ, F4, C3, CZ, C4, P3, PZ, P4 nine point N400 wave. Compare N400 wave latency, amplitude, and differences in behavioral responses between each group. Data were processed using analysis of variance, t-test,χ2 -test, Spearman correlation analysis.Results:1. Clinical aphasia examination: aphasia group were tested by the ABC examination identified 8 cases of BGA, Broca aphasia in 5 cases,2 cases with TCM. Auditory comprehension, repetition, naming, reading scores of aphasia group were lower than the case-control group (P<0.05).2. In both groups, the results of MMSE and P300 were normal, but the performances of MMSE were lower in aphasia group than in case-control groups (P<0.05).3. N400 examination:comparison N400 latency, amplitude, and behavioral reaction time and accuracy differences between each group.3.1 Aphasia group compare with the control group: the N400 latency of aphasia group were longer than in the normal control group (P<0.05).the N400 latency of aphasia group were longer than in the case-control group bur was not statistically significant.3.2 Comparison of different parts: The latency of F3, C3-lead in aphasia group were longer than other records (P<0.05). N400 amplitude recorded in aphasia group leads compare the control group had no significant differences (P> 0.05).3.3 Comparison of different stimuliate: Start stimulation: N400 starting latency of aphasia group, case-control group and the normal control group were slowed more when start as a sentence than a pictures (P<0.01). Target stimuli: the N400 amplitude between aphasia group, case-control group and the normal control group showed no significant difference (P> 0.05). There are no differences between noun and verb.3.4 The latency of ERP induced by sentence recorded in F3 and C3 lead in brain injury patients with aphasia check entry to read the "choice of words fill in the blank" was a positive correlation, N400 amplitude with no correlation.3.5 The response time and the correct rates were longer (P<0.001) and lower (P<0.001) in the experimental than in control groups, respectively. The response time and the correct rates was longer (P<0.05) and lower (P<0.001) in sentences than pictures.Conclusion: 1. Chinese language may have the following characteristics of cognitive processing: frontal and central district may play an important role in the language semantics and syntax processing; frontal and central district may be play an important role in the semantics process of nouns and verbs in early generation; early semantic processing of verbs and nouns networks may overlap; brain cognitive process were sensitive to picture as a start stimulation.2. N400 can be used for assess language function of aphasia patients after brain injury, but needs further study. |
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