Analysis Of Risk Factors For Cervical Cancer And Cervical Intraepithelial Neoplasia In Mongolian Womenfrom Inner Mongolia

Object:to evaluate the efficiency of cervical cancer and cervical intraepithelial neoplasia screening based on local doctor performed VIA and VILI test, and to investigate the main risk factor for cervical cancer and its epidemiology in women from pastoral area.Methods:cervical screening using VIA and VILI test was conducted on women aged from 30 to 59 from Mongolian inhabited pastoral area in Inner Mongolia, including Uxin Qi in Ordos city, Horqin Youyi Zhongqi in Hinggan city and Horqin Zuoyi Zhongqi in Tongliao city. Women positive in VIA or VILI underwent colposcopy and biopsies were taken from the abnormal areas observed in colposcopy for histological diagnosis. Same procedure was used for rechecking. The efficiency of the screening was evaluated by comparing the result of the screening in first year and second year, at the same time the risk factors for cervical cancer was also investigated. The questionnaire includes demographic information, marital status, and family history of diseases and behavioral characteristics. Logistic regression. x2 testing and T testing was used for statistical analysis by SPSS 13.0.Results:between 2008 and 2009, a total of 6002 women were screened. The proportion of CIN1, CTN2, CIN3 and cervical cancer in the first year screening (6002) and second year rechecking (4609) was 0.92%,0.15%,0.07% and 0.1% and 0.43%, 0.17%,0.02% and 0, respectively. Between 2009 and 2010, a total of 6008 women were screened. The proportion of CIN1, CIN2, CIN3 and cervical cancer in the first year screening (6008) and second year rechecking (4459) was 0.52%,0.23%,0.03% and 0.12% and 0.18%,0.02%,0 and 0, respectively. In 12010 women underwent screening between 2008 and 2010, the proportion of CIN1, CIN2, CIN3 and cervical cancer was 0.95%,0.27%,0.06% and 0.11%, respectively. Of them,75.44% of CIN1, 72.88% of CIN285.71% of CIN3 and all of the cervical cancer cases were detected in the first round screening. A total of 166 (1.38%) women were diagnosed as intraepithelial neoplasia or worse. The proportion of cervical diseases differs significantly across three areas (p<0.05), significantly higher in Wuxin Qi than the other two areas. Univariate logistic regression analysis shows that associated risk factor for cervical cancer includes, alcohol, smoking, number of pregnancy, number of birth, cervical inflammation, urinary tract inflammation, cervical erosion, age and age of first intercourse. Multivariate logistic regression analysis shows that the factors: alcohol, smoking, cervical inflammation, number of birth and age of first intercourse can increase the risk for cervical cancer and CIN.Conclusion:CIN and cervical cancer screening based on trained local doctor performed VIA and VILI test is feasible for in less developed rural area. The mass cervical screening should focus on western area of Inner Mongolia. Smoking, alcohol, the age of first intercourse, cervical erosion, cervical inflammations and the number of birth are the risk factors for cervical cancer in women from pastoral area.