Clinical Study On Angina Pectoris Of CHD Treated With Guanxintongmai Capsule

Objective:To observe the influence of Guanxintongai capsule on nitric oxide (NO)High sensitivity C-reactive protein(Hs-CRP) and Endothelin(ET) of patients who suffered angina pectoris of the disease of coronary heart disease and make clear the effects by treating with the Guanxintongmai capsule in order to explore the probably mechanisms, and give us some credible scientific basis for the clinical application.Methods:Sixty patients with angina pectoris were randomly divided into two groups:Treatment group(n=30) treated with guanxintongmai capsule and the control group (n=30) with tongxinluo capsule for four weeks. then we analyze the levels of ET/NO/hs-CRP between the patients.Results:Effective treatment of patients ECG observed in 24 cases, 4 cases, the total effective rate of 85.7%, while the control group,27 cases of effective cases and ineffective in 3 cases, the total efficiency of 90.0% Compared with this it has no Significant difference between two groups (p>0.05); Effective treatment of patients clinical binefis observed in 26cases,2 cases, the total effective rate of 92.9%, while the control group,28 cases of effective cases and ineffective in 2 cases, the total efficiency of 93.3% Compared with this it has no Significant difference between the two groups (p>0.05); NO by the treatment group before treatment (87.24±9.31)umol/l up to (110.17±9.35)umol/l, it has Significant difference between the two groups, ET from the before treatment (118.12±31.67)ng/l down to (99.46±24.98)ng/l, it has Significant difference between the two groups; Hs-CRP by the treatment (8.55±2.34)mg/l decreased to (4.97±2.13)mg/l, it has Significant difference between the two groups; but NO from the control group before treatment (88.93±8.45)umol/l up to (113.52±7.88)umol/l, it has Significant difference between the two groups; ET decreased from (121.5±33.94)ng/l down to (102.21±28.76)ng/l, it has Significant difference between the two groups; Hs-CRP by the treatment (8.61±2.18)mg/l decreased to (5.34±2.37)mg/l, it has Significant difference between the two groups;At last we found that the Indicators of two groups has its significant difference.Conclusion:Guanxintongmai capsule has significantly influence on NO, ET, Hs-CRP for protectioning of endothelial function.