Studies On Zedoary Turmeric Oil Microemulsion

Zedoary Turmeric oil microemulsion, choosing zedoary turmeric oil as the model durg,was thermodynamically stable oil-in-water microemulsion. The main effective chemical constituents are volatile oils, which are proved by pharmacology experiments that can be anti-virus, improve immunity.Most dosage forms of zedoary turmeric oil had excitability and low bioavailability. Therefore, microemulsion was selected as the carrier to prepare the oral solution to increase stability,advance absorption.First,we collect some correlative data literature of Curcuma phaeocaulis to determine Curcuma phaeocaulis'effective chemical ingredients, pharmacology effect and chemical quality,which point the way of how to design the technology. By orthogonal test and single factor compared,practicable extraction technology is selected. The contents of Curcumol in the rude medicinal materials Curcuma phaeocaulis Extraction are measured. To investigate pseudo-ternary phase diagram and titrimetric method to select Ezhu oral microemulsion's formular and fabricating technology; Use transmission election microscope and laser particle size analyzer to determine the form and size distribution of the system, study on the identification of Ezhu;carry out the stability research of Zedoary Turmeric oil oral microemulsion. We established the quality standands for Ezhu microemulsion. The results of the experiments are as follow:The slecttion of the extraction technology:Compared extraction by SD and SFE, the curcumas'content of extraction by SD is higher; Using the orthogonal design, the size reduction, the distillation time, the water,extraction time are considered. The optimization of the extraction technology is:Curcuma wenchowensis sp. Nov, the size redution 20-40, the distillation time 8h, the water 8 times of the amount。The study of preparation of Ezhu microemulsion:the effects of different cosurfactants,oils,pH and ionic strength of water,salinity,temperature,preparation and release medium,the revolving speed of the basket are considered through the effect of the tablet' s molding technology and drug released-degree in vitro were investigated. Ethanol was used for CoSf,Ethyl butyrate as oil. Prescription proportion was:zedoary turmeric oil 12.Og,Tween-80 4.2g,distilled water 10.00g,emulsifying temperature 40℃,magnetic stirring 100r/min,20min,pH6.5。The study of quality standard of Ezhu oil microemulsion:(1) Description:The liquid is dim yellow and round, adhibit and greasy, bitter. The relative density is 1.03458; The mean value of pH is 6.5; The mean size diameter is 78 nm. (2) Check:The microemulsion weight diversity accords to the CHP 2010 standard, so does the microbe limitation. (3)Quantity identification:By chemical methods for identification. The spot in chromgraph is clear and distinct, recurs well, has no disturbance by its controlled simple. (4) Quality analysis:The content of cuucumol in microemulsion is measured by UV. It was required to 187.5mg/ml. (5) Preliminary stability tests:Ezhu oil microemulsion was stable in 3 months.Above all, the zedoary turmeric oil microemulsion is stable, reliable,safe. Not only conforms to the chacateristics of microemulsion,but the results have showed that it's also a new carrier system for traditional Chinese drugs.