Comparison Study Of Firefly-Technology Ultrasound And Mammography For The Diagnosis Of Breast Lesions With Microcal Cification

ObjectiveTo explore the diagnostic value of mammography and firefly-technology in the diagnosis of breast lesions with microcalcification.MethodsOne hundred and thirty two patients with breast lesions with microcalcification in Shandong provincial hospital underwent operation or histological biopsy, and the pathologic diagnosis was obtained. There was no any history of biopsy, physical therapy, radiotherapy or operation that were comfirmed in all patients before the digital mammography and firefly-technology ultrasound were both performed.All firefly-technology ultrasound was performed using TOSHIBA US systerm with linear array high frequency probe, the frequency of which was 13MHZ. The patients adopted supine position when bilateral breasts were comprehensively examined by ultrasonograph, and multi-section and multi-angle scanning were used to discover breast mass. Using lower gain conditions and multi-angle scanning showed microcalcification. The size, edge, shape, internal echo, mass drive aspect ratio, pone attenuation and blood flow condition of the lesions were recorded. The nature of the breast lesions was analysed and judged . All mammography examinations were undertaken with full-field digital mammography, which was GE digital plate molybdenum target mammary machine with high definitional tachy-collcetion workstation and high resolution display's browsing station. The patients adopt standing position. Mammography examination used Craniocaudal View(CC) position and Medio Lateral Oblique View ( MLO) position, adding lateral position and zoom photograph if necessary. The size, shape and distribution of the microcalcifications in breast lesions and the size, shape, margin of the lesions were observed and recorded. Again the nature of the breast lesions was analysed and judged. Statistical analyses: The sensitivity, specificity, accuracy, false negativity rate, positive predictive value and negative value for firefly-technology ultrasound and mammography diagnosis were calculated. The sensitivity, specificity, accuracy, false negativity rate, false negativity rate, positive predictive value and negative value for the combination of firefly-technology ultrasound and mammography diagnosis were calculated too. Statistical data was treeted with statistical software of package SPSS13.0. Chi-square test is applied for enumeration data and P<0.05 for the differences was statistically significant.ResultsThe detection rate of firefly-technology ultrasound for the breast microcalcifications was 72.7%, and was as high as 90.0% for the breast malignant lesions and only 37.2% for the breast benign lesions. The sensitivity, specificity, accuracy, false negativity rate, false negativity rate, positive predictive value and negative value of firefly-technology were 73.0%, 81.4%, 75.8%, 11.0%, 40.7%, 73.0% and 81.4% respectively. The sensitivity, specificity, accuracy, false negativity rate, false negativity rate, positive predictive value and negative value of mammography were 77.5%, 67.4%, 74.2%, 16.9%, 40.8 %, 77.5% and 67.4% respectively. The sensitivity, specificity, accuracy, false negativity rate, false negativity rate, positive predictive value and negative value of the combination of firefly-technology and mammography were 92.1%, 90.7%, 91.7%, 4.7%, 15.2%, 92.1% and 90.7% respectively. Mammography has a high sensitivity, and firefly-technology ultrasound has a high specificity for the detection of the microcalcification of the breast lesions. The combination of the two examinations could improve the diagnostic accuracy of the microcalcifications in breast lesions.Conclusion1.Firefly-technology ultrasound used for the detection of the microcalcifications in breast lesions has a certain advantages, particularly in the breast malignant leisions. It can show the characteristics of the breast lesions, such as disease patterns, borders, the echo of the situation, the rear echo attenuation and blood flow situation.2.The diagnostic accuracy of the Firefly-technology ultrasound and Mammography was similar. The firefly-technology ultrasound has a high specificity and mammography has a higher sensitivity for the display of microcalcification in the breast lesions. They are both an ideal method for the breast lesions with calcification.3.The combination of the firefly-technology ultrasound and mammography has a higher accuracy for the diagnosis of the breast lesions with microcalcification than using either modality alone. The firefly-technology and mammography have a complete advantage when they are used to detect the breast lesion with microcalcification.