Mainly In Treating Children Cold Cough Clinical Research. Professor Kong Guangyi Academic Thinking And Clinical Experience And Qing Xuan

ObjectiveBy collecting and researching the clinical medical records and experience on children cough of Professor Kong Guangyi who is from Beijing University of Traditional Chinese Medicine,we try to find out their academic origin and summarize the academic thoughts, clinical experience, to promote the depth of academic inheritance, also to clarify personal learning and experiences, so as to deepen and enhancing the understanding. Evaluation efficacy and safety of clearing solution in children with heat-caused cough, we explore the characteristics fitting the progress of Chinese medicine, according to the experience of the old Chinese medicine practitioners, and to promote their speculative research methods on academic thought and clinic experience.MethodsLiterature research is using qualitative research methods for Professor Kong Guangyi's academic thinking, clinical experience, literature review in the past 20 years; theory research is including putting traditional literature in order, modern literature analysis, in-depth interviews, clinical learning with the teacher by combination of practice and academic thinking of Professor Kong Guangyi, to summarize and organize his clinical experience.Part of clinical evaluation is using a prospective cohort study method, from June 2008-June 2011, at the Chinese medicine clinic Guo Yi Tang of Beijing University of Traditional Chinese Medicine and Beijing Drum Tower Hospital. The pediatric patients included who were wind-heat common cough in children and met the inclusion criteria included in the study, they were divided in basic intervention, Western intervention, intervention by medicine pills, traditional Chinese medicine clearing and draining solution (reducing the heat of the surface detoxification in the lung) decoction intervention. All groups are exposure, freely to enter any queue, observation period is 28 days, and traditional Chinese medicine decoction treatment more than 5 days, then evaluation on the end point, disease duration, severity of cough and other indicators of efficacy. Evaluation is according to Response Evaluation industry-standard Criteria specified in State Administration of Traditional Chinese Medicine of People's Republic of China:"Chinese medicine Diagnosis and treatment in pediatrics ZY/T001.4-94".We used SPSS 16.0 statistical analysis system, general information using descriptive analysis and data using syndromes frequency analysis, measurement data with analysis of variance, t test; level data with Ridit analysis, Kruskal-Wallis rank sum test method; count data compared with theχ2test (Chi-square Test). Unified hypothesis testing using two-sided test, given test statistic and its corresponding P value to P≤0.05 as significant statistically significant, with P≤0.01 as highly significant statistically significant. Results3.1 Literature research and theoretical studiesThe formation of Professor Kong Guangyi's academic thinking and clinical experience concludes his interpretation of the depth of TCM, the emphasis on the first diagnosis, focusing on differentiation, paying attention to the overall, lapping temperature and disease, academic innovation, good at healing fever deseases, erupting evil, good at all subjects, sincere benevolence, wholehearted participation in the Chinese and Western medicine, focusing on research and academic thinking, and a special treatment of exogenous fever, cough in children, uterine bleeding, dysmenorrhea, mastitis, complex diseases, clinical experience and his Herbal Prescription characteristics.3.2 Clinical Research114 patients were enrolled and 91 cases in the case group and 23 cases in control group, loss 8 cases, the total loss rate is 7.02%,five cases in the case group and 3 cases in the control group.2 cases in control group and 5 in case group live far from the hospital, they were lost because lost keep in touch by telephone.1 case in the control group asked to leave because of dissatisfaction with treatment trials.106 patients were included in the analysis, 58 cases were male, accounting for 54.72%, female 48, accounting for 45.28%. Minimum age is 0.5 years, maximum 11.0 years, median age is 4 years with an average age of 4.388±0.2009 years of age. The shortest duration of 1 day, the longest duration of 7 days, average 3±0.166 days. Cough visual analogue score to take the degree, a minimum of 5 minutes, up to 10 points, on average. The shortest duration is 1 day, the longest duration is 7 days, average 7.23±0.128 points.80 patients were cured in the case group, accounting for 93.0%,6 cases improved, accounting for 6.98%,0 cases ineffective; 15 cases were cured in the control group, accounting 75%,5 cases improved, accounting 15%.χ2test,χ2= 5.667, P= 0.017<0.05, shows the overall efficacy of the two groups has a significant difference, according to the mean the case group is significantly better than the control group. If recovery can be seen the end of the event, statistic the time required for recovery, the longest is 27 days, and minimum is 3 days, an average of 9.62±0.598 days. Case group is 8.55±0.530 days, the control group is 14.25±1.917 days.%test,χ2= 64.487, P<0.001, shows the overall efficacy of the two groups has a significant difference, according to the mean, the case group was significantly shorter in recovery period than the control group. According to Cough visual analogue scale level, compared to the pre-treatment, after treatment has an average of 5.023±0.508 points reducing, paired sample t test, t= 91.663, P<0.001, shows the overall efficacy of the two groups has a significant difference, according to the mean of comparison, the case group is significantly better in easing cough. Security aspects were included 106 cases in the analysis, there were 2 cases occurred adverse events, both in the case group, and both diarrhea, perhaps has some relationship with the coldness and bitterness of clearing heat herbs. by symptomatically maintaining water and electrolyte balance, the adverse symptoms were eased after stopping the drugs.Conclusions:4.1 The academic systems and clinical experience of Professor Kong Guangyi is systematic and profound, so a lot of summing up work remains to be further improved.Professor Kong Guangyi has formated a unique academic thinking and clear theoretical system in febrile diseases, and he has accumulated rich clinical experience and good efficacy with exogenous fever. Professor Kong is proficient in internal medicine, gynecology, pediatric, coronary heart disease, stomach disease, menstrual and many other deseases. The unique insights and experience of medication, clinical law are worthy of further speculative mining.4.2 clearing solution-based diagnosis and treatment of cough in children with exogenous wind-heat is effective and safe.106 patients through the prospective observation, the total efficiency of clear solution treatment of children with common cough wind-heat type is 100% and cure rate is 93.0%, significantly better than Chinese patent medicine, Western medicine and other treatment. The average healing duration is of 8.55±0.530 days, significantly shorter than Chinese patent medicine, Western medicine and other treatment.7 days of cough relief virtual visual score was 4.811±0.393 points, which is better than Chinese patent medicine, Western medicine and other treatment. Although there were minor adverse reactions such as diarrhea, overall security is good.4.3 The heritage and research of old Chinese academic's good thought, experience, is fruitful, but still need to study further in the method exploration.Through literature research, in-depth interviews, we can confirm that the heritage and research on old Chinese academic's thought and experience has made a lot of advantages, national ten five, eleven five project on clinical experience has also obtained fruitful results. At the same time we cannot deny that the inheritance of clinical experience is still lack of methodology, and is still in a relatively weak state, lack of public acceptable research methods. There is still defects and bias in the design and implementation of Chinese medicine integrated approach which is to be further improved.