Cough Powder Compatibility Law Of The Treatment Of Chronic Cough

Background:Chronic cough means the cough has continued more than eight weeks, and the cough is the main or the only symptoms, the chest X-ray has found nothing.On account of the high morbidity, the complexity of etiological factor, the serious psych-disturbance, and the terrible influence to humans'life, chronic cough has becomes one of the pressing medical problems. Many clinical observations indicated that the anagraph (plus-minus to "zhi sou san") has significant curative effect on the treatment of chronic cough. But owing to the difference of those plus-minus methods, the curative effect has significant disparities, and there still be many troubles to the clinicians which want to practice this prescription.Objective:This topic was planning to compare the plus-minus methods of modern doctors of traditional Chinese medicine and my teacher Mr.miao's plus-minus methods (about the anagraph "zhi sou san" on the treatment of chronic cough). From this, we can find a frequent regularity of the compatibility with "zhi sou san". It may improve the curative effect of Chinese medicine on the treatment of chronic cough, and provide a dependable evidence to the treatment of chronic cough.Methods:1.Literature research (including the literatures in medicine magazine and the literatures about famous-old Chinese medicine doctors):Collect and arrange those literaturesk:Record the frequent dosage of "zhi sou san", the distribution of accompanied symptoms and signs, the distribution of simultaneous phenomenon, and the distribution of Chinese herbal medicine (except those drug which "zhi sou san" has had) in those literatures. Through analyzing those data, we can get a frequent plus-minus method of "Zhi Sou San"2.Clinical research:Colleting 44 chronic cough patients (Xiyuan Hospital of China Academy of Chinese Medical Sciences, from September,2010 to April 2011), and give the herb tea (plus-minus to "Zhi Sou San") to those patients. Then record the scores of cough, scores of Chinese medicine symptom, scores of LCQ questionnaires, and the cough's harmful effects. Analyzing the scores of prior-treatment and post-treatment, then estimate the availability of the anagraph (plus-minus to "Zhi Sou san"). At the same time, we can collect the accompanied symptoms and signs of those cases, the simultaneous phenomenon of those patients, the distribution of Chinese herbal medicine. So that, we can find the plus-minus method of "Zhi Sou San" which is Mr.miao's experience.Results:1.Through analyzing those literatures data, we can get four ramification:①The frequent dosage of "Zhi Sou San":Fineleaf schizonepeta herb 10g, Dried Tangerine peel 10g, Tatarian Aster Root 10g, Stemona Root 10g, Willowleaf Swallowwort Rhizome 10g, Platycodon Root 10g, Radix Glycyrrhizae 6g;②The frequent simultaneous phenomenon:Wind-cold assault lung, Wind-heat assault lung, Wind dryness harm lung, Phlegmatic-hygrosis heap in lung, Sputum-heat heap in lung, Deficiency of QI in lung and spleen, Lung-YIN deficient,Hepatic fire harm lung, Stagnated blood obstruction lung, Kidney-QI deficient, Summer hygrosis heap in lung;③The frequent accompanied symptoms and signs:Gasping, Throat distress, Hoarse voice, Nasal obstruction or nose running, Dry cough or few sputum, Mass in chest and gastric cavity, Spasmodic cough, Constipation, Nocturnal cough, Anorexia or abdominal distension, Insomnia, Vomitus and so on;④The frequent plus-minus method of "Zhi Sou San" from those literatures, just as:When part-timing Wind-cold assault lung, we can add Ephedra, Beef-steak plant leaf, Divaricate-saposhnikovia, Hogfennel root, Almond, Pinelliae tuber, Manchurian wildginger, Fresh ginger, Cassia twig, Common coltsfoot flower; When parting Wind dryness harm lung, we can add Almond, Dwarf lilyturf tuber, Tendrilleaf fritillary bulb, Root of straight ladybell, Figwort root, Chinese magnolivine fruit, Cortex mori, Thunberg fritillary bulb, Hogfennel root, Periostacum-cicadae; When following Gasping, we can add Ephedra, Almond, Common coltsfoot flower, Allolobophora caliginosa trapezoides, Pepperweed seed, Fructus perillae, Magnolia bark, Chinese magnolivine fruit, Periostracum cicadae; and so on.2.Through analyzing the data of the clinical research, we can get six ramification:①According to the norm of curative effect, we can compute out the curative effect:The clinical control rate of Chinese medicine symptom is 9.09%, excellent power is 54.55%, effective power is 29.54%, ineffective power is 6.82%; The clinical control rate of cough is 31.82%, excellent power is 43.18%, effective power is 20.45%, ineffective power is 4.55%;②Through analyzing the scores of prior-treatment and post-treatment, we can see:After those patients cpalend the herb tea (plus-minus to "Zhi Sou San"), their cough, all simultaneous phenomenon of Chinese medicine (except the condition of emptying the bowels), quality of life have been improved, and the changes have statistical significance (P<0.05)③The frequent harmful effects of cough:Hoarse voice, Insomnia, Headache, Chest complaint, Anxiety, Embarrassment, Fear to disease, Interacting work, Interrupt telephone, Dodge public place, and so on.④The frequent simultaneous phenomenon:Wind-cold assault lung, Wind-heat assault lung, Wind dryness harm lung, Phlegmatic-hygrosis heap in lung, Sputum-heat heap in lung, Deficiency of QI in lung and spleen;⑤The frequent accompanied symptoms and signs:Hoarse voice, Throat distress, Insomnia, Nocturnal cough, Nasal obstruction or nose running, Vomitus, Dry cough or few sputum, Anorexia or abdominal distension, Gasping, Mass in chest and gastric cavity, Constipation, and so on;⑥The plus-minus method of my teacher in the "Zhi Sou San", just as:When parting Wind-cold assault lung, we can add Beef-steak plant leaf, Almond, Ephedra, Pinelliae tuber, Fresh ginger, Cassia twig, Dried ginger, Notopterygium;When parting Sputum-heat heap in lung, we can add Tendrilleaf fritillary bulb, Almond, Ephedra, Gypsum, Baical skullcap root, Bamboo shavings, Benincasae semen, Pinellia tuber, Indian bread, Immature orange fruit; When following insomnia, we can add Fossilia ossis mastodi, Oyster, and Spine date seed; When following Nasal obstruction or nose running, we can add Siberian cocklebur fruit and Biond magnolia flower; and so on.Conclusions:1. From the plus-misus methods of my teacher and the literatures, we can see some concomitances: When part-timing Wind-cold assault lung, we can add Beef-steak plant leaf, Almond, Ephedra, Pinelliae tuber, Fresh ginger, Cassia twig; When part-timing Wind-heat assault lung, we can add Almond, Baical skullcap root, Peppermint, Weeping forsythia capsule, Tendrilleaf fritillary bulb; when part-timing Wind dryness harm lung, we can add Almond, Dwarf lilyturf tuber, Tendrilleaf fritillary bulb, Periostacum cicadae; When part-timing Sputum-heat heap in lung, we can add Baical skullcap root, Ephedra, Gypsum, Almond; when part-timing Phlegmatic-hygrosis heap in lung, we can add Pinellia tuber, Indian bread, Perillaseed, White mustard seed, Radish seed, Magnolia bark; When following Hoarse voice, we can add Almond, Loquat leaf and Periostracum cicadae; When following Nocturnal cough, we can add Almond and Periostracum cicada; When following Gasping, we can add Almond, Ephedra, Common coltsfoot flower, Pepperweed seed, Loquat leaf, Periostracum cicadae; When following Throat distress, we can add Almond, Periostracum cicada, Great burdock achene, Belamcandae; When following Nasal obstruction or nose running, we can add Siberian cocklebur fruit and Biond magnolia flower; When following Dry cough or few sputum, we can add Periostracum cicadae, Almond, Loquat leaf and Tendrilleaf fritillary bulb; When following Mass in chest and gastric cavity,we can add Bupleuri and Orange fruit; When following Anorexia or abdominal distension, we can add Hawthorn, Massa medicata fermentata, Malt; When following Insomnia, we can add Spine date seed; When following Vomitus, we can add Pinellia tuber and Fresh ginger; But there are also some differences between two methods in the Nocturnal cough, Hoarse voice, Vomitu, Insomnia, Mass in chest and gastric cavity, and other kinds of symptoms.2.According to the clinical research, we can see the plus-misus to " zhi sou san" is available in the treatment of Chronic cough.