Chronic Cough Cough Wind Permit Card Due To The Law

ObjectiveThrough observation of the etiological factors, predisposing factors, medical history, quality of life, four kinds of diagnostic information in chronic cough patients with pathogenic wind-induced cough syndrome, the cross-sectional study method was used, the factor analysis and multiple linear regression analysis were applied to summarize the characteristics of the pathogenic wind-induced cough syndrome in chronic cough, so as to reveal the rules in syndrome and pathogenesis and provide the basis for clinical treatment.Methods1. Relevant literature on chronic cough in Chinese and Western medicine were summarized, especially TCM literature on research of pathogenic wind-induced cough syndrome in ancient and modern times.2. The cross-sectional study method was used, the etiological factors, predisposing factors, medical history, quality of life, and four kinds of diagnostic information in chronic cough patients with pathogenic wind-induced cough syndrome were collected through questionnaires.3. Factor analysis and multiple regression analysis were used for statistical analysis of the collected data to study and summarize the rules in syndrome and pathogenesis of pathogenic wind-induced cough syndrome in chronic cough.Results1. A total of 445 cases of patients with pathogenic wind-induced cough syndrome were observed, while 9 cases were excluded and 436 cases completed the observation, including 119 males and 317 females; aged 18-88 years old, mean age of 50.38±13.77 years; most patients with pathogenic wind-induced cough syndrome were in the age group 45-59.2. Features of disease onset:The predisposing factors of the first onset were predominated by external contraction; the factors to induce the onset or worsening of cough were predominated by inhalation of fumes/dust, changes in environmental temperature, odor or pungent odor, and external contraction. The first onset and the onset and exacerbation of cough mainly occurred in winder, followed by Autumn and Spring.3. The impact of cough on quality of life:Cough had affected patients' physiology, psychology, and social intercourse in varying degrees. Compared with males, females got lower physical and psychological scores, with significant difference (P<0.05). Furthermore,82 (18.81%) patients (all female) had urinary incontinence caused by coughing.4. Distribution of concurrent and accompanied syndromes:It mainly included 7 concurrent and accompanied syndromes:Lung yin deficiency, damp-heat accumulation, dryness-phlegm obstructing the lung, pathogenic heat accumulation, lung yang deficiency, lung qi deficiency, and qi counterf low due to stomach heat.5. Relevant factors affecting concurrent and accompanied syndromes:Under the guidance of TCM etiology, on the basis of the factor analysis, multiple linear regression method was used to analyze the major risk factor of concurrent and accompanied syndromes, obtaining the equation of linear regression:Damp-heat accumulation factor y=-1.366+0.314X7+0.302X2+0.019X12, indicating that predilection for greasy and rich foods, an older age, previous treatment with antitussive/antibechic drugs affected the occurrence of damp-heat accumulation syndrome more greatly.Lung yang deficiency factor y=-0.246+0.799X10, indicating that predilection for cold drinks affected the occurrence of lung yang deficiency syndrome more greatly.Lung qi deficiency factor y=-0.397+0.794X7+0.224X17+0.091X12, indicating that predi lection for greasy and rich foods, excessive contemplation, previous treatment with antitussive/antibechic drugs affected the occurrence of lung qi deficiency syndrome more greatly.6. Analysis of the correlation between main concurrent and accompanied syndromes and duration:spearman correlation analysis showed that among the main concurrent and accompanied syndromes, lung qi deficiency was positively correlated with the duration (P<0.01).Conclusions1. Clinically, pathogenic wind-induced cough syndrome is a common syndrome in chronic cough, with a higher incidence in females. Pathogenic wind-induced cough can be found in all age groups, with the highest incidence in middle-aged group. Its duration has no significant sex differences; it can affect the quality of life of patients in different degrees. The characteristics of onset can be presented in seasonal correlation, mainly in winter; its predisposing factors were extensive.2. Etiology and pathogenesis:Pathogenic wind-induced cough is caused by a combination of external contraction and internal damage. The external cause is pathogenic wind invasion; the internal causes are dysfunction of organs and accumulation of pathological products. The disease location is mainly in lung, and related with liver, heart, spleen, lung, kidney and stomach.3. Principal syndrome and concurrent and accompanied syndromes:pathogenic wind fettering lung syndrome is the principal syndrome; lung yin deficiency, damp-heat accumulation, pathogenic heat accumulation, dryness-phlegm obstructing the lung, lung yang deficiency, lung qi deficiency, and qi counterf low due to stomach heat are the main concurrent and accompanied syndromes. Among them, lung qi deficiency syndrome is correlated with the duration.4. Factors affecting the concurrent and accompanied syndromes:predilection for greasy and rich foods, an older age and previous treatment with antitussive/antibechic drugs are major risk factors of damp-heat accumulation syndrome; predilection for cold drinks is the major risk factors of lung yang deficiency syndrome; predilection for greasy and rich foods, excessive contemplation are the major risk factors of lung qi deficiency syndrome.