| Objective:To investigate the efficacy of basic fibroblast growth factor (bFGF) combined with topical oxygen therapy for deepⅡdegree burn wounds, by comparing the effects of bFGF combined with topical oxygen therapy and bFGF with routine therapy.Methods:From February 2004 to July 2009,85 patients with deep II degree burn wounds (117 wounds) were enrolled and divided into 4 groups randomly according to different treatments. There was no signifi cant difference in sex, age, disease course, wound size, and wound treatment size among 4 groups (P>0.05).In group A,18 patients (28 wounds) were treated routinely; in group B,23 patients (30 wounds) were treated with routine methods and topical oxygen therapy; in group C,19 patients (25 wounds) were treated with routine methods and bFGF therapy; and in group D,25 patients (34 wounds) were treated with routine methods and bFGF/topical oxygen therapy.Topical oxygen therapy was administered to the wound for 90 minutes per day for 3 weeks. The bFGF therapy was applied everyday (150 U/cm2) for 3 weeks.Results:All cases were followed up 6-12 months (9 months on average). The wound healing times in groups A, B, C, and D were (27.3±6.6), (24.2±5.8), (22.2±6.8), and (18.2±4.8) days, respectively;showing signifi cant difference between group A and group D (P< 0.05). The wound healing rates in groups A, B, C, and D were 67.8%±12.1%, 85.1%±7.5%,89.2%±8.3%, and 96.1%±5.6%, respectively; showing signifi cant differences between group A and groups B, C, D (P<0.05). The therapic effective rates in groups A, B, C, and D were 75%,90%,92%, and 100%,respectively; showing signifi cant difference between group A and group D (P<0.05). The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A (P<0.05).Conclusion:The bFGF combined with topical oxygen therapy can enhance deepⅡdegree burn wound healing. |
PDF Full Text Request