The Related Risk Factors Of Anomaly Of Albumin To Creatinine Ratio In Early-onset Type 2 Diabetes

Objective: By discussing clinical characteristics and risk factors of patients with early-onset type 2 diabetes suffering anomaly of albumin to creatinine ratio(ACR) we can earlier and better control risk factors of patients with early-onset type 2diabetes , thus delaying the development of diabetic nephropathy.Methods: We selected 924 hospitalized patients with diagnosis of type 2 diabetes from Jan. 2010 to Jan. 2011 in the Department of Endocrinology of the Second Affiliated Hospital of Dalian Medical University. Among them, 329 cases'diagnosis age is less than 40 years old and 595 cases'diagnosis age is over 40 years old. Depending on different ACR, the 329 cases were divided into two groups, patients with early-onset type 2 diabetes suffering anomaly of ACR ( 172 cases; male: ACR≥17mg/g, female: ACR≥25mg/g ) and patients with early-onset type 2 diabetes not suffering anomaly of ACR ( 157 cases) and the 595 cases were also divided in two groups patients with late-onset type 2 diabetes suffering anomaly of ACR ( 284 cases; male: ACR≥17mg/g, female: ACR 25mg/g ) and patients with late-onset type 2 diabetes not suffering anomaly of ACR ( 304cases). General information of patients, biochemical and clinical data were compared and clinical characteristics and risk factors of patients with early-onset type 2 diabetes suffering anomaly of ACR were analyzed.Results:1. Compared to late–onset type 2 diabetes, subjects with early- onset type 2 diabetes had higher proportion of anomaly of ACR (52.3% vs 47.7%) (P> 0.05). Patients with early-onset type 2 diabetes aged under 35 years old had the highest proportion up to 61.2%. and male patients had higher proportion(P< 0.05).2. Average duration of patients with early-onset type 2 diabetes suffering anomaly of ACR was obviously shorter than that of Patients with late-onset type 2 diabetes suffering anomaly of ACR and subjects with early-onset type 2 diabetes suffering anomaly of ACR had higher proportion of FPG, HbAlc, TG and diabetic retinopathy(DN) but lower proportion of 2hINS, 2hC-P and Homab, compared to subjects with late-onset type 2 diabetes suffering anomaly of ACR(P< 0.05).3. Compared to subjects with early-onset type 2 diabetes not suffering anomaly of ACR, subjects with early-onset type 2 diabetes suffering anomaly of ACR had higher BMI, waist circumference, hip circumference, higher levels of FPG, 2hPG, HbAlc, TC, TG, SUA, Scr and higher possibili- ty of diabetic macrovascular disease, diabetic peripheral neuropathy and diabetic retinopathy. (P< 0.05)4. By multivariate logistic regression analysis, HbAlc,TG, BMI and SUA were identified as independent predictors of anomaly of ACR(P< 0.05).Conclusion:1. Early-onset type 2 diabetes has higher proportion of anomaly of ACR and average duration of patients with early-onset type 2 diabetes suffering anomaly is short. Patients with diagnosis age under 35 has the highest proportion of anomaly of ACR and male has higher proportion compared to female.2. HbAlc, TG, BMI and SUA are independent predictors of anomaly of ACR. Early prevention, diagnosis and intervention can prevent and delay the development of diabetic nephropathy.