High-frequency Ultrasound In Evaluation On Impact Of Glycosylated Hemoglobin To Carotid Intima-medial Thickness And Remodeling Of Carotid Atherosclerosis For Type 2 Diabetes Mellitus Patients

Objective:To observe the impact of glycosylated hemoglobin (HbA1c) on intima-medial thickness (IMT) of carotid and remodeling of carotid atherosclerosis in type 2 diabetes mellitus (T2DM) patients with high-frequency ultrasound.Methods:A total of 100 patients with T2DM were divided into two groups according to the level of HbA1c, including 51 with HbA1c level less than 9% in group A and 49 with HbA1c level greater than or equal to 9% in group B Meanwhile,50 healthy subjects were enrolled in group C as normal controls. All T2DM patients and healthy subjects were examined with high-frequency ultrasound. The IMT of carotid, total vessel area (TVA) and lumen area (LA) of the vessels in which atherosclerotic plaque could be found were measured, while the remodeling index (RI) and the total plaque score were calculated. Moreover, the detection of HbA1c was performed, and the relationship between HbA1c and carotid IMT was analyzed.Results:The IMT of the trunk, bifurcation site of common carotid artery, the internal carotid artery,the average IMT and the total plaque score in group A and B were higher than those in group C (all P<0.05). The IMT and the total plaque score in group B was higher than those in group B (all P<0.05). Positive correlation was observed between HbA1c and the average IMT in group A and B (P<0.05).The remodeling rate of carotid atherosclerosis in group A and B was higher than that in group C(P<0.05).There was no statistical difference of remodeling rate between group A and B.The negative remodeling rate of group B was higher than those of group A and C (P<0.05),while no statistical difference was found in group A and C. The rate of positive remodeling was higher than that of negative remodeling in group A and C (all P< 0.05),while the rate of negative remodeling was higher than that of positive remodeling in group B (P<0.05).Conclusion :In T2DM patients,HbA1c is closely correlated with carotid IMT,and the remodeling of carotid atherosclerosis is influenced by HbA1c. High-frequency ultrasound is a convenient and precise method in assessing the the impact of HbA1c on IMT of carotid and remodeling of carotid atherosclerosis in T2DM patients.