Study On Radiotherapy-induced And Chemotherapy-induced Disorders Of Glucose Metabolism In Patients With Malignant Tumor

Objective:Detect the levels of blood glucose, Insulin and C-Peptide in patients with malignant tumor before and after the radiotherapy and chemotherapy, Study on radiotherapy-induced and chemotherapy-induced disorders of glucose metabolism in patients with malignant tumor, and makes a preliminary study of the mechanism.Methods:All of the patients with the malignant tumor were not pancreatic cancer or hepatocellular carcinoma, also do not have diabetes history, we received 113 control values of blood glucose, insulin and c-peptide in the 79 patients of before the chemotherapy; 30 control values of blood glucose, insulin and c-peptide in the patients of before and after radiotherapy; 19 control values of before the first chemotherapy and after the last chemotherapy, and 16 control values of before and after chemotherapy. All of the values of blood glucose, insulin, c-peptide, HOMA-IR and HOMA-%βin the patients before chemotherapy are analyzed with the course of treatment.Result:The values of the insulin and c-peptide are increased after the whole cycles of chemotherapy(P<0.05); The values of the insulin and HOMA-IR are positive relevant with the times of chemotherapy within the past time.Conclusion:The insulin, c-peptide levels are increased after the whole cycles of chemotherapy, and the insulin levels will be higher and it will be insulin resistant with the more cycles of chemotherapy.