Study On Chemotherapy-induced Glucose Metabolic Disorders And Function Of P Ell Of Islet In Patients With Malignant Neoplasm

Objective: To determine the infuence of chemotherapy on glucose metabolism and onfunction ofβCell of islet in patients with malignant neotlasm.Methods: We selected250malignant neotlasm cases accepted different chemotherapyschedule from January2005to December2006and analyzed the cases retrospectively,according to the blood glucose assay, function ofβCell of islet function ofβCell of isletIL-6assay and TNF-α assay associated clinical materials before and afterchemotherapy. Meanwhile, we detect Variation of C-peptide after one month threemonths of chemotherapy and observe the effect of various factors on the glucosemetabolism.Results: The blood glucose and function ofβCell of islet after chemotherapy was moreincreasing than that before chemotherapy (P<0.05). The blood glucose and functionofβCell of islet after four periods chemotherapy in85cases of142cases was moreincreasing than that before chemotherapy (P<0.05). Hormone utilization andadministration route affect The blood glucose and function ofβCell of islet. BMI indexwhich is positive correlation with blood glucose may become risk factors (Exp (B)>1).Operation history which is passive correlation with blood glucose may becomeprotection factors (Exp (B)<1). Age, ECOG score, G-CSF utilization history and injuryof liver renal function are not correlation with blood glucose. Regard to alkylatingagents and other chemotherapeutics, Platinum and plants chemotherapeutics are morecorrelation with glucose tolerance abnormal. Possibility of glucose tolerance abnormalwhich is correlation with chemotherapy period and drug accumulation was rise after four periods chemotherapy.After chemotherapy,patients with normal glucose tolerancein pancreatic β-cell function have a more higher and faster recovery rate.Conclusion:(1) Chemotherapy can lead to fasting glucose, fasting C-peptide, fastinginsulin levels′rise, cause insulin resistance, and even develop into diabetes in thetreatment of malignant tumors.(2)During chemotherapy, the using of hormone is oneof the factors of abnormal glucose metabolism.(3)Regard to alkylating agents and otherchemotherapeutics, Platinum and plants chemotherapeutics are more correlation withglucose tolerance abnormal.(4)Patients with malignant tumors should be noted that tomaintain body weight in the normal range, obesity may lead to aggravate abnormalglucose metabolism.