| 1. Objective:To observed the clinical effects of nourishes yin falls the fire side to prevent and control its side effect in the nephrosis syndrome large dose hormone treatment stage,Discuse the prevention possible pathogenesis of nourishes yin falls the fire side to be the result of the Yin deficient positive high card to the large dose sugar cortical hormone treatment stage. With the thought of "to govern has not gotten sick" as instruction,,2. Data and Methods:1. The cases originated from May,2010 to February,2011 Wuhan integrated TCM& western medicine hospital Cooperation of Chinese and Western medicine Hospital Nephrosis Internal medicine department outpatient service and the hospital ward in-patient, there were 61 patients tally integrate the standard, And 46 patients had the kidney puncture pathology material, witch had the small pathological change (MCD) 30 examples, the department membrane proliferative renal glomerulus nephritis (MsPGN)5 examples, the membrane nephrosis (MN)4 examples, the bureau stove stage renal glomerulus to harden (FSGS) 4 examples, the membrane capillarity vascular renal glomerulus nephritis (MCGN)3 examples. The cases divided into the western group 29 examples and the cooperation of chinese and western medicine group 32 examples stochastically. At the end,3 examples were rejected Because of serious complication in the western group. The viewing time were 8 weeks, treated before and after lweek,2weeks,4 weeks,8 weeks respectively.2. The western group was treated:the standard dosage hormone (Prednisone), adjust the fat, the antifreeze and the just right for the illness support treatment, and the rest, high thermal, the low fat high quality protein, the protosalt diet in the acute stage; The cooperation of Chinese and Western medicine group was treated:the above treatment added the traditional Chinese medicine, planed the side to nourish yin falls the fire side (zhimu, huangbo, shengdi, biejia, nvzhenzi, hanliancao, fuling, sha nyao), and clinical along with card addition and subtraction.3. Observed the appearances of side effect in the two group of patients (five hearts to be sultry, mouth sobs, facial color blood flushes, acne, dizziness tinnitus, disgusting vomit, infection, digestive tract hemorrhage dry) in the large dose hormone treatment stage. Observed the changes of chinese medicine card and chinese medicine symptom integral change between the two groups before and after treatment. Observed the clinical efficacy of traditional Chinese medicine and Western medicine, relevant laboratory parameters (24-hour urinary protein, serum albumin, serum creatinine), and analyzed statistically. 4. Processed with the SPSS17.0 statistics software package, the measurement material (x±s) indicated by the mean value±standard deviation, around the group compares uses two independent sample T-test, in the group treats compares uses the pair sample T-test, the counting material comparison uses the card side examination.3. Results:1. The eside effect formation rate of western medicine group was 64.3%, wihle The cooperation of Chinese and Western medicine group was 35.7%, analyzed the non-significance difference after statistics (t=1.51, P>0.05); But the appearances of of the Yin deficient positive high card(five hearts is sultry, mouth sobs, facial color blood flushes, acne, dizziness tinnitus the aspect occurrence to have the significance difference dry) in the cooperation Chinese and Western medicine group had the significance difference with Western medicine group (P<0.05).2. The acne's formation rate of cooperation of Chinese and Western medicine group was 15.6%, and the doctor practicing western medicine group was 57.7%, there were significance difference between the two groups (x2=11.2, P<0.01)3. Compared with Chinese medicine card, the spleen kidney deficiency of yang card in western medicine group before and after treatment was statistically significant compared (x2= 6.84, P<0.05); the gas cloudy two empty cards in western medicine group before and after treatment was statistically significant compared (x2= 10.01, P<0.01). After the treatment, the gas cloudy two empty cards and the spleen kidney deficiency of yang card in the cooperation Chinese and Western medicine group had statistics significance compared with Western medicine group (x2=6.34, x2=5.92, P<0.05).4. Compared with Chinese medicine symptom integral, the hepatorenal Yin deficient card and the gas cloudy two empty cards had statistics significance before and afte treatment in Western medicine group (12.50±0.71,16.50±1.38; 11.25±1.50,14.35±2.31; t=3.80, t= 2.51,P<0.05). After treatment, the hepatorenal Yin deficient card and the gas cloudy two empty cards in Cooperation of Chinese and Western medicine group had statistics significance which compared with Western medicine group (16.50±1.38,14.35±2.31; t=4.49, t= 5.98; P<0.01).5. Compared with the clinical efficacy of Western medicine, the total effectiveness of Cooperation of Chinese and Western medicine group was 93.8%,and the Western medicine group was 65.4%, there were statistics significance (x2=4.03, P<0.05). Compared with the clinical efficacy of traditional Chinese medicine, the total effectiveness of Cooperation of Chinese and Western medicine group was 90.6%, and the Western medicine group was 69.2%, there were statistics significance (x2=4.27, P<0.05).6. Compared with 24-hour urinary protein:there were statistics significance (t=4.48, P<0.01) in the Western medicine group before and afte treatment (4.90±1.53,2.33±1.38); the cooperation of Chinese and Western medicine group was the same (6.06±2.00,1.04±0.92, t=8.97, P<0.01); Compared with the serum albumin:there were statistics significance (t=4.19, P<0.01) in the Western medicine group before and afte treatment (25.19±6.10,33.18±5.98); and the cooperation of Chinese and Western medicine group was (23.89±5.01,39.41±3.93, t=9.17, P<0.01), had statistics significance. After the treatment, the 24-hour urinary protein and the the serum albumin in the cooperation Chinese and Western medicine group had statistics significance compared with Western medicine group (t=3.02, t=3.37, P<0.01).5. Conclusion: To observe the clinical effect of nourishes yin falls the fire side in large dose hormone treatment stage for the nephrosis syndrome patient, discoved the appearances of Yin deficient positive high card (five hearts are sultry, mouth sobs the appearance which dry, facial color blood flushes, acne, dizziness tinnitus) in cooperation of Chinese and Western medicine group was less than the Western medicine group. Compared with the occurrence of acne, the cooperation of Chinese and Western medicine group was superior to the Western medicine group, and the control of the Yin deficient card and symptom integral had the effect than the Western medicine group. Toke "governs has not gotten sick" the thought as the instruction, treated with nourishes yin falls the fire side and hormone at the same time for the nephrosis syndrome at large dose hormone treatment stage, had effect of preventing and controling Yin deficient positive high card witch was caused by the hormones. |
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