Photoacoustic Signals Analysis And Its Medical Applications Based On Focused Scanning Photoacoustic Imaging

Photoacoustic imaging technology (PAT) is an emerging and noninvasive biomedical imaging technology. It takes the optical imaging technology with high contrast and high resolution together with the ultrasound imaging feature of high penetration depth.It has the advantages of optical imaging and ultrasound imaging as an organic combination. PAT can be used with other imaging techniques to form multi-modality imaging. It has broad application prospects in the biomedical field. In this thesis, based on focused scanning photoacoustic imaging technique, the relationship between the photoacoustic spectroscopy signal and the physiological characteristics of organizations have been studied. We also explored the PAT in biomedical applications, such as accurate positioning of the needle and the detection of thrombus. The results demonstrated that photoacoustic imaging has the feasibility about accurately guiding the acupuncture. The main contents of this thesis are as follows:Firstly, the progress of photoacoustic imaging technology by domestic and international research groups are presented. The development of studies on photoacoustic signal detective technology and biomedical application specific examples are reviewed in detail.Secondly, the physical principles of photoacoustic imaging technology is introduced, the photoacoustic effect included.Thirdly, a comprehensive description of our photoacoustic imaging system is given.Fourthly, a focused scanning photoacoustic imaging system was employed to simulate all kinds of acupuncture treatment. The main experimental results show that photoacoustic imaging technology can locate the needle and the simulated blood vessels very well. It is feasible to guide doctors and nurses while doing accurately injection.Fifthly, the physiological characteristics of human tissue and the principle of photoacoustic spectroscopy are presented, in order to identify the relationship between them.The thesis also provided the prime research on photoacoustic imaging applications in the detection of thrombosis.