The Correlation Study Among Fibrinogen, Apolipoprotein AⅠ Level And The Short-term Prognosis Of Patients With Acute Coronary Syndrome After PCI

Objective:The purpose of this study was to investigate the possibility of the prediction about the short-term prognosis of patients with acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI) by Fibrinogen(FIB) and Apolipoprote AⅠ( ApoAⅠ) so as to provide a theoret-ical basis for ACS treatment by observing the relationship between FIB and ApoAⅠlevel of the patients with ACS who received PCI and the incidence rate of patients'major adwerse cardiac events(MACE) within 30 days after PCI.Methods: Measurements the FIB, ApoAⅠand ApoB level of 121 subjects with ACS who received PCI after admission and 64 healthy subjects, and record the patients'general information as well. According to the serum cardiac markers level, ACS patients were divided into two groups: unstable angina(UA) group (n = 53) and acute myocardial infarction(AMI) group (n = 68), comparing them with healthy persons'FIB, ApoAⅠand ApoAⅠ/ ApoB ratio. According to FIB level, ACS patients were divided into two groups: GroupⅠ(n = 83): FIB<4g/l;GroupⅡ(n = 38): FIB≥4g / l; According to the ApoAⅠlevel ,they were divide into another two groups: GroupⅠ(n = 78): ApoAⅠ≥1.0 g / l; GroupⅣ(n = 43) ApoAⅠ<1.0 g/l. We compare the occurrence of the patients'MACE(including malignant arrhythmia, no reflow, slow reflow during PCI and angina pectoris, severe arrhythmia, congestive heart failure, ventricular aneurysm, cardiac shock, death after PCI ) after PCI for 30 days between GroupⅠand GroupⅡ,and between GroupⅠand GroupⅣrespectively. So we can analyze the risk factors which influence the short-term prognosis of patients with ACS after PCI.Results:1. AMI group's FIB level was significantly higher than that of FIB UA group and the control group (P<0.01);And the UA group and the control group showed no statistically significant difference(P>0.05).Comparing UA group , AMI group with the control group, we found ApoAⅠsignificantly lower (P<0.01), while the AMI group's ApoAⅠlevel was significantly lower than that of UA group (P<0.05).2.We made AMI group and UA group compare with control group, finding that ApoAⅠ/ApoB ratio between them had significant difference(P<0.01).While the comparison of AMI group and UA group had no statistically significant difference(P>0.05).3. Concerning some elements of MACE(including severe arrhythmia, congestive heart failure, ventricular aneurysm, cardiac shock, death after PCI ) after PCI, GroupⅡ's incidence rate was increased more than that of GroupⅠ, but GroupⅣwith congestive heart failure element was increased more than that of GroupⅠ(P<0.05).The total MACE incidence rate between GroupⅡand GroupⅠ, GroupⅣand GroupⅠhad both a significant difference in statistics. (P<0.01).Conclusion:1. FIB level in patients with AMI is significantly raised, and FIB level is not significantly raised in patients with UA.2. ACS patients'ApoAⅠlevel and ApoAⅠ/ ApoB ratio are significantly lower, which is the main risk factors.3.The one with FIB≥4g / l and ApoAⅠ<1.0g/l, who may occur MACE after PCI has a significantly higher rate than that of the control group, suggesting that FIB and ApoAⅠlevel are the major risk factors to influence the short-term prognosis of patients with ACS after PCI.