| Objective: To observe the changes of serum Superoxida dismutase(SOD) and Malon- dial dehyde (MDA) in patients with acute cerebral infarction. To research the relationship between the level of SOD MDA and the severity of disease . Research and application of berberine on the efficacy and influence of acute cerebral infarction and brain tissue..Methods: Select 56 patients with cerebral infarction for CI group (cerebral infarction),in which 32cases of conventional group ,24 cases used berberine,and 45cases of healthy acted as control group .Both were comparable in age ,gender composition. The Enzymatic colorimetric assay was used to detect the level of serum MDA and SOD. Observe the changes of SOD,MDA in patients with acut cerebral infarction within 48 hours of onset and the first 10 days after admission . Observe the changes of SOD,MDA in patients with Berberine group and the conventional group within 48 hours of onset and the first 10 days after admission . The neurological deficits of patients with CI were assessed by U.S. National Institutes of Health Stroke Scale(NIHSS).The results were dealed with the statistical software SPSS 16.0. P<0.05 means the difference has statistical significance.Results:1. Incidence of cerebral infarction within 48h and 10d after admission serum SOD levels were significantly higher than those in the control group (P <0.01), admission 10d 48h of serum SOD levels than the increase in incidence, but the difference was not significant.Incidence of cerebral infarction within 48h and 10d after admission levels of serum MDA was significantly higher than those in the control group (P <0.05), serum MDA levels after admission 10d 48h than the increased incidence, but the difference was not significant.2. NIHSS score of cerebral infarction and SOD levels showed a significant negative correlation value (P <0.05), incidence of hospital admission and after the 10d 48h of serum SOD, MDA levels and NIHSS score had no significant correlation.3. Berberine group level after admission 10d SOD levels than the same period in the conventional group was significantly higher (P <0.05), MDA berberine group difference with the conventional group were significantly different (P <0.01), SOD group difference of berberine Compared with the conventional group were significantly different (P <0.05). 48h berberine group, SOD levels of morbidity were no significant differences compared with regular, twice the level of MDA compared with the same period there was no significant difference between the conventional group.4. Incidence of cerebral infarction in SOD levels of hospital admission and 48h at the same time the level of MDA was significantly negatively correlated (P <0.05). 10d after admission serum SOD levels and incidence of hospital admission within 48h values of MDA levels were significantly negatively correlated (P <0.01). And 10 days after admission the level of serum SOD and MDA levels of the same period, no significant correlation. Incidence of hospital admission, SOD levels and 48h for 10 days after admission serum MDA levels were not significantly correlated.Conclusions:1. Patients with acute cerebral SOD, MDA levels were significantly increased. Tip SOD and MDA may be involved in the pathophysiology of acute cerebral infarction.2. Condition improved in patients with acute cerebral infarction was significantly more elevated levels of serum SOD more obvious, suggested that serum levels of SOD may be related to the severity of the disease.3. Berberine in acute cerebral infarction can be significantly increased levels of serum SOD, serum MDA levels decreased, suggesting that berberine may be involved in the process of scavenging oxygen free radicals, may be useful to improve the prognosis of acute cerebral infarction.4. SOD levels in patients with acute cerebral infarction and MDA levels were significantly negatively correlated, suggesting that both in the pathophysiology of acute cerebral infarction there may be some connection... |
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