Studies On The Chemical Constituents Of Kadsura Coccinea (Lem.) A. C. Smith

Kadsura coccinea (Lem.) A. C. Smith belongs to the Schisandraceae family, the Kadsura genus, widely distributed in the southern part of China, including Hubei, Guangdong, Guangxi, Sichuan, Yunnan, Guizhou provinces. As a climbing plant, it is mainly used for treatment of rheumatoid arthritis, acrobatics wrench, dysmenorrhoea, chronic gastritis and duodenal ulcers in folk medicine. Recently, a considerable number of studies have been performed on the Kadsura plants. These investigations have yielded dibenzocycloctadiene lignans and lanostane triterpenoids, with pharmacological properties including antihepatitis, antihepatotoxic, antioxidant, anti-inflammatory, antitumor, and anti-HIV activities.Total 22 compounds were isolated from 95% EtOH extracts of K. coccinea after extracted through CHCl3 and EtOAc successively. All of them were elucidated by various modern spectroscopic techniques and based upon their physical properties, including one new dibenzocyclooctadiene named Kadsuralignan L (22). Besides that, six compounds were isolated from the genus for the first time, and three compounds were firstly isolated from this plant. The new compound Kadsuralignan L (22) was tested for its effects on NO production inhibitory activity using macrophage RAW264.7 cells. Kadsuralignan L (22) showed moderate NO production inhibitory activity with an IC50 value of 52.5μM.In addition, the research of chemical constituents and pharmacological activities of Kadsura genus were reviewed in this paper to reasonablely exploit its medicinal values.