The Effects Of Different Target-controlled Infusion Concentration Of Remifentanil To The ECe50 Of Propofol With Target-controlled Infusion In Eldly Patients

Objective To investigate the effects of different target-controlled infusion concentration of remifentanil to the ECe50 of propofol with target-controlled infusion in eldly patients.Methods Sixty patients aged 65-85, undergoing transurethral resection of prostate,were divided randomly into three groups(R0.5, R1.0, R1.5) with 20 cases each and given remifentanil with the target concentration of 0.5 ng/ml,1 ng/ml,1.5 ng/ml, respectively. Propofol was performed when remifentanil reached to the target concentration.All the patients were received oxygen five minutes with mask before operation. Propofol was given by up and down method according to the movement of body when the No 27 olympus resection endoscope was put into the urethra and the ratio of two close effect concent rations was 1.2.The effect-site infusion concentration of propofol is 1.2 ug/ml,1.4 ug/ml,1.7 ug/ml,2.0 ug/ml,2.4 ug/ml,2.9 ug/ml,3.5 ug/ml.The results of MAP,SpO2,HR,CSI were recorded by UP-8000 cerebral state monitor.Results The ECe50 of the R0.5 group was 2.37 ug/ml. The 95% confidence interval was 2.22-2.53 ug/ml. The ECe50 of the R1.0 group was 1.84 ug/ml. The 95% confidence interval was 1.75-1.94 ug/ml. The ECe50 of the R1.5 group was 1.66 ug/ml. The 95% confidence interval was 1.60-1.71ug/ml.Conclusion The increasing of target-controlled infusion concentration of remifentanil help to decrease the ECe50 of propofol,but the danger of anesthesia will be bigger accordingly.