| Objective The thesis aims to develop a joint detection of serum pepsinogen (PG),PG subsets (PGI,PGⅠ/PGⅡ) and gastric cancer-related antigens (MG7-Ag), and to discuss the significance of the detection in gastric cancer diagnosis and prognosis.Method Latex-enhanced immunoturbidimetric and ELISA test are respectively used to detect PG(PGⅠ,PGⅠ/PGⅡ) and MG7-Ag contents in the serum of all the subjects, and the results are processed statistically.Results The contents of serum PG Ⅰ, PG Ⅰ/PG Ⅱ (PGR) in the gastric cancer group after surgery are significantly lower than those in control groups(P<0.01);the contents of serum PGI and PGR in the atrophic gastritis group are significantly lower than those in the healthy, gastric ulcer and superficial gastritis groups (P<0.05); the contents of serum PGI in the gastric ulcer and superficial gastritis group are significantly higher than that in the healthy group (P<0.05). On the other hand, the content of serum MG7-Ag in the gastric cancer group is significantly higher than that is control groups (P<0.01); the content of serum MG7-Ag in the atrophic gastritis group are significantly higher than that in the healthy, gastric ulcer and superficial gastritis groups(P<0.05). The positive rate of the joint detection for gastric cancer diagnosis and prognosis was up to90%. The contents of PGI, PGR and MG7-Ag have no significant differences due to the subjects'age and gender(P>0.05).The PGI and MG7-Ag contents are significant lower in gastric cancer patients after surgery(P<0.01), but if recurrence occurred, the PGI and MG7-Ag contents would increase significantly(P<0.05).Conclusion (1)The joint detection of Serum PGI, PGR and MG7-Ag contributes to the pre-diagnosis of gastric cancer and differential diagnosis of gastric benign lesion.(2)The positive rate of the joint detection of Serum PGI, PGR and MG7-Ag in gastric cancer patients is far higher than that of any single project detections.(3)The joint detection of Serum PGI, PGR and MG7-Ag contributes to the prognosis of recurrence and transfer after surgery. |
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