Wheat Starch, Dietary Intervention Study The Reversal Effect Of Early Renal Damage

Background and Aims:To study the effect of wheat starch supplementation on early diabetic nephropathy.Materials and Methods:The type 2 diabetic patients were from our inpatients and outpatients, and were subgrouped into DM-A subjects who was with microalbuminuria (UAER between 20～200μg/min)and normal diet, and DM-B subjects who were with microalbuminuria (UAER between 20～200μg/min) and wheat starch diet, and DM-C subjects who were with macroalbuminuria(UAER>200μg/min) and normal diet, and DM-D subjects who were with microalbuminuria (UAER>200μg/min) and wheat starch diet. Subjects were given intervention for 3 month. Demographic details, and information on family history of diabetes, personal history of illness and other lifestyle risk factors were collected. A Standard 75g oral glucose tolerance test was performed to all the participants. Blood pressure, body weight, height, waist and hip circumference, blood glucose(BG),blood lipid, Glycosylated Hemoglobin(HbA1c), insulin(INS) and Microalbuminuria(MAU).Results:After dietary intervention wheat starch, DM-B group UAER is 20～200μg/min, called the intervention decreased significantly (P<0.05), and B2-MG, TRP and NAG significantly lower than normal diabetic diet group, the difference was statistically significant (P< 0.05). The DM-C group and DM-D group was no significant difference in UAER (P> 0.05).Conclusion:Wheat starch diet can improve early diabetic nephropathy, but the group (UAER>200μg/min)can not have significant improvement.