Cans Spa Vivo Transdermal Absorption Of Ligustrazine Hydrochloride

The research method of traditional Chinese medicine can pay TMP transdermal-gel TMP rabbits after transdermal absorption, further investigation can pay for physical therapy to promote infiltration. Through a comparison between HPLC method of determination, inspected the ethanol, chloroform, dichloromethane, petroleum ether 4 organic enrichment effects of solvent on tetramethylpyrazine in blood, identified as trichloromethane enrichment of tetramethylpyrazine in blood the best organic solvents.And has carried on optimal to the organic solvent extract condition, designed the law with the orthogonal experiment to inspect the different chloroform amount used (5ml,6ml,7ml), the supersonic time (12min,16min,20min), the whirlpool time (3min,5min,7min) to the rhizome of Ligusticum wallichii qin extract effect influence, the determination best extract condition:chloroform dosage for 7ml, ultrasonic time of 12min, Eddy 3min, blood content of ligustrazine in the highest; Stick internal release of pharmaceutical carry on content determine by piperazine to Rhizoma Chuanxiong, investigate through special attribute its, standard foundation, precision and rate of recovery of curve test, the result indicate that accords with two appendixⅪⅩB requirement that " the human living beings of medicine preparation utilize degree and experimental guideline equivalently of living beings "s of 2005 version of " Chinese pharmacopoeia ". In addition, by orthogonal experimental design method study on the different tank (tanks, tank skid tanks, fibrillation), pressure (low, medium, high), a different tank treatment time (5 minutes, 10 minutes,15 minutes) on the amount of cumulative penetration of ligustrazine hydrochloride effects, determine the best tank therapy methods, conditions:Cupping is slip tank, the pressure is the pressure tank treatment time is 5 minutes. Comparative pharmacokinetics of optimal group and blank group parameters, DAS by pharmacokinetic analysis software version 2.1.1, be analysed data:the blank area under the curve of the Group of 595.5, area under the curve of the optimal group of 7549.725, optimal Group about 10 times higher than the blank group times. Research has further proved that the treatment can be used as a new drug for the physical and skin penetration in the way for a substantial increase in drug and skin, provide a set of new and practical, efficient and reliable way.