| Pain is a common symptom of cancer patients, about25% of the new cancer patients, and more than30% of the receiving treatment for cancer patients and70%of the advanced cancer patients are with pain, usually cancer pain patients live shorter, if they have not received the right pain treatment, patients may suffer long-term of pain, and greatly influence the overall quality of life of them, such as activities, sleep, and mood, etc. Effective control of cancer pain, the greatest degree of improve the quality of life, is not only the right of patients, but also the duty of doctors'. According to the three steps of pain by the WHO treatment on the principle of the standardization of the cancer treatment, can make the most of the patients with cancer pain be better ease. In recent years, the traditional Chinese medicine with its unique theory system, using herbal internal and external use, acupuncture, and other methods, the research on the treatment of cancer pain research, has obtained the satisfactory progress. Traditional Chinese medicine for pain medicine has wide medicine source, low prices and analgesic time is long, the advantages of few side-effects, widely used in recent years.Through the long-term clinical practice and its observation, Chief physician Yang Yufei thought cancer pain for cold evil main etiology of long meridians, influence the body fluid to promote the normal operation of the qi movement, and cold phase beat, get together and become phlegm, however sturbborn phlegm is not to go, so new blood can produce difficultly, stasis and don't turn. Therefore, in the treatment of cancer pain, cold is scattered fundamental, remove stasis battles the phlegm, both supplement each other, urgent then treat the standard, slow then treat this, both supplement each other, and finally the fundamental control patients with pain. The prescription is formed by the1g Raw aconite root,1g Raw Kusnezoff Monkshood Root,1g Dragon's blood powder,1g Raw arisaema cum bile,1g Raw Banxia,0.5g Preparation of nux vomica;0.5g Borneol,0.5g Realgar etc. Clinical observation will meet eligibility criteria of30cases of patients with random into the group successively, group1first topical experiment agent3days, elution period stopped3days, to use3days a placebo. Group2first for external use only three days placebo, elution period stopped3days, to use3days experimental agent, the subjects and the observer using a double blind.The results showed that cross two groups before and after, age, sex, and whether using painkillers, whether to accept the radiotherapy and chemotherapy have no significant differences on baseline, but in KPS scores are statistically significant. The pain score of experimental group and placebo treatment before treatment-after treatment,Z=0.96, P=0.923>0.05; The heaviest pain chi-square test shows the curative effect, the chi-square=0.136, P=0.713>0.05; The two groups after treating the lightest pain when the drug inspection by the rank and drug-before difference Z=0.336, P=0.737>0.05; The lightest pain chi-square test shows the curative effect, the chi-square=2.228, P=0.136>0.05; Two groups before and after treatment by the pain impact assessment t test t=0.792, P=0.436>0.05; Two groups before and after treatment by the rank and sleep influence degree inspection Z=0.143, P=0.887>0.05; The two groups work time is Z=0.134, P=0.894>0.05; Two groups of curative effect is the time function, the Z=0.044, P=0.965>0.05; Two groups of skin adverse reaction degree after a chi-square test, P=0.667>0.05; As can be seen, the above results were greater than0.05P value, there was no statistically significant difference; The pain and the role the effect-acting period in duration, P>0.05, no statistical difference; In the skin adverse reactions, P>0.05, there was no significant differences, analysis from the Falling off cases, more patients is out of the placebo and its experimental agent not better clinical curative effect and refuse to use.From clinical observation and analysis of experimental results, there was no obvious difference between the test drugs and placebo effect, we should consider the following reasons:first, Chinese traditional medicine external treatment of pain through skin absorption rate is low. Topics by random double-blind design, musk for gas unique fragrance, not according to the original oncology at the commonly used four wonderful scattered join musk rely solely on the Borneol, the guiding effect is poorer; This experiment though did five cases of the experiment, but no animal tests to handle and improve absorbed through skin. Second, honey for water soluble substances, traditional Chinese medicine composition complex, which may exist some alcohol-soluble material does not very good dissolved out, and then not have local WenTong channels role. There may be a need to use vinegar or alcohol as a vehicle to use. Third, between the two groups before the treatment KPS (health) score different, because cancer pain is a comprehensive treatment, so may influence the results of the experiment, it is a factor; Fourth, the patients, psychologic factors and the quality of life are important parts in the treatment of cancer pain, active therapy of original disease also is a crucial factor; Fifth, for ache degree>6points or<5points, namely the severe and mild patients, this has influenced the experiment result to a certain extent. Sixth we also used the three degree analgesic drug in this experiment at the same time, the great effect of them concealed the analgesic effect of the experimental drug to a certain extent. The seventh, Chinese traditional medicine topical agent mainly absorbed through the skin, to local play a scattered by the temperature cold role, and the need for certain blood drug concentration can alleviate visceral pain of something is not obvious.From the5cases and the placebo group4cases of effective observed cases, pain in the abdominal pain in4cases, liver area pain in2cases, periumbilical pain in2cases, right lower quadrant abdominal pain in1, and the four kinds of pain in the abdomen are located; For pain character, a dull ache in5cases, colic3cases, sting in1. Because of the small Sample volume and can't see the difference of the existing among them, and for experimental drug treatment of abdominal pain whether there are certain advantages, can be more of sample size. |
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