Research Of Left Ventricular Myocardium Strain In Essential Hypertension Patients By2D-STI

Essential hypertension is a multi-gene genetic disease which caused bycombination of many factors, heart is one of its main target organ.Therefore anaccurate assessment of changes in cardiac function in EH patients is veryimportant for the prevention and timely treatment.This research includes two parts:1.Assess myocardium strain of eachsegment of left ventricular in healthy people by two-dimensional speckletracking imaging,to explore the strain law of the left ventricularmyocardium.2.Assess myocardium strain of each segment of left ventricular inEH patients by two-dimensional speckle tracking imaging, and compare withcontrol group, in order to evaluate the systolic function of left ventricular.Purpose:This study investigates the application of assessing myocardiumstrain and systolic function of left ventricular in EH patients usingtwo-dimensional speckle tracking imaging.Methods:This research based on case-control study,40healthy volunteerswere selected as control group,40EH patients were selected as hypertensiongroup, these40EH patients were divided into two groups in accordance withGanau classification:①21cases of left ventricular normal geometry(group B);②19cases of left ventricular remodeling (groupC).Philips IU22color doppler ultrasonic diagnostic equipment was used in thisresearch. ECG was performed simultaneously. Measure the diastolic diameterof left ventricle, diastolic interventricular septal thickness, left ventricularposterior wall thickness.Measure left ventricular ejection fraction by theSimpson method. Each take the average of three measurements. Images wererecorded from the LV apical four-chamber view, three-chamber view,two-chamber view and the short-axis views at the levels of mitral valve,papillary muscle and apex of the LV respectively. Analyze these recorded images by Qlab. Use SPSS13.0statistical software for data processing.Results:1The peak of longitudinal strain curve in each segment of LV in healthypeople were negative,which is in systole,and the peak of LS graduallyincreased from base to apex.2The peak of radial strain curve in each segment of LV in healthy people werepositive,which is in systole.When three short axis levels RS peak were compared with each other, thelevel of the papillary muscle is higher than the mitral valve level and the apexlevel, the difference was statistically significant (P <0.01).3The peak of circumferential strain curve in each segment of LV in healthypeople were negative,which is in systole.The peak of CS values among the three short axis weredifferente, the apexlevel were higher than the mitral valve level and the papillary muscle level,the difference was statistically significant (P <0.01).4The shape of strain curve in control group were regularly while inhypertension group were disordered.5LA were larger in group A than group B(P <0.05),Compared with group Aand group B,the values of IVSd, LVPWd, LVMI had no significant difference(P＞0.05); The values of IVSd, LVPWd and LVMI were significantly higherin group C when compared with group A and group B(P＜0.01), there was nosignificant difference in LVEF between the three groups (P>0.05).6Compared with group A,the LS peak values in each segment and the globalLS peak values in group C were reduced(P＜0.05).7In group B,the RS peak values were higher than thoes in group A.The RSpeak values in group C is lower than group B in papillary muscle level andapex level(P＜0.05),and have no statistically significant when compare withthe control group.8The CS value had no significant difference in three short-axis level andglobal CS among the three groups.Conclusion: 1Changes in LV myocardial strain already performed before the decline of thesystolic function.Changes of the local LV function in EH patients can be foundin early stage by STI.2Two-dimensional speckle tracking imaging can evaluate global and local LVfunction accurately and quantitatively.