Metal Porphyrin Dendrimer And 4,6 Bis-substituted Indole, Indazole Compounds The Design And Synthesis Of Research

The application in medicine and pharmacy, and also the characteristics of the structure of dendrimers were summarized briefly in the first part of this paper. Taking tetra-phenyl porphyrin as the synthetic core, we designed, synthesized a series of novel metal Cu²⁺ porphyrins. A porphyrin phosphate was obtained, by using tetra-phenyl porphyrin and dibenzyl phosphiteas as the starting materials through phosphatation and hydrogenation. Through Micheal addition, hydrogenation etc, we also prepared building blocks from benzylamine, tert-butyl bromoacetate, tert-butyl acrylate or bromoacetyl bromide.The porphyrin core was linked with the building blocks by forming ether or ester bonds to give four dendrimers of the first generation and one of the second, and their structure were confirmed by ¹H-NMR, MS. The inhibition activities against the active oxidant of these water-dissolved metal porphyrins were also tested.In the second part of this paper, the synthetic routes of 4,6-disubstitued indoles and indozoles were introduced. We prepared four 4,6-disubstitued indoles from substituted o-nitrotoluene through reductive cyclization ; Using substituted o-aminotoluene as the starting material, through diazotization, cyclization, eleven 4,6-disubstitued indazoles were obtained. All of the target molecules' structures were confirmed by ¹H-NMR, MS.