Synthesis Of Ethyl 7-Hydroxyl-6-Methoxylquinoline-3-Carboxylate Derivatives

Virosis is one of the most common infectious diseases in human. Influenza viruses, hepatitis viruses and human immunodeficiency viruses are described and the corresponding antivirus drugs used in clinic are also introduced. 5-hydroxyl-lH-indole-3-carboxylates have been reported to have potent antiviral activity and Abidol hydrochloride which inhibits the replication of influenza viruses through the activation of 2,5-oligoadenylate synthetase, has been used against influenza viruses of the A and B antigenic types.Based on the structure-activity relationship of 5-hydroxyl-1H-indole-3-carboxylates, taking Abidol hydrochloride as the leading compound, we change the indole ring into the quinoline ring. Thus, 7-hydroxyl-6-methoxylquinoline-3-carboxylates are designed and modifications are made at the 2 position and 8 position. 21 new compounds are synthesized and their structures are confirmed by MS and ~1H-NMR.The pharmacological evaluation of the target compounds is in process.