A Dynamic Model On Active Substances Extraction Process Of Nature Products

Natural products have been widely used to prevention and treatment of humandiseases. The extraction and purification process of active substances and the researchof increasing extraction rate have been one of the important topics of natural products.According to the report, the extraction process of effective components for naturalproducts is most using experience or most curve fitting experimental data to define theparameter values. The extraction process of active substances for natural products is acomplex mass transfer process, and the extraction process is affected by many physicalchemistry factors, such as: extraction temperature, particle size, concentration and ratioof solvent to solid. At present, dynamic study of natural products extraction process isstill lack of the systematically theoretical analysis, this study is the breakthrough pointof this paper. Based on mass transfer process of active substances in the extractionprocess, established the dynamics model can objective description the extractionprocess of natural products. And the related theoretical analysis and experiments verifythe model. The model can provide important theoretical support for the extractionprocess of effective component for natural products.This topic qualitatively describes theory foundation of the extraction process ofnatural products. Based on the second law Fick diffusion, the dynamic model isestablished considering the adsorption and function decomposition. The model candescribes the relationship of extraction rate and operating conditions (extractiontemperature, particle size, concentration and ratio of solvent to solid). The modelproposes three performance indicators (extraction rate and extraction time) to depict theextraction process. In addition, dynamic model is verified by the experiment ofchlorogenic acid production in mixing reflux extraction. The operating parametersunder different conditions can well match the calculated values of proposed dynamicmodel of chlorogenic acid extraction process. So, the dynamic model of the extractionprocess of natural products provides a new ideas and methods in the design parameters.The main research work and corresponding results were done in this thesis. liquid adsorption, and brings in the decomposition coefficientk Dfor the hightemperature, the liquid adsorption massm afor small particle. So, the dynamic modeladapt to the extraction process of natural products.②By solving the dynamic model, the relationships of the extraction rate and theinfluencing parameters and intrinsic property are obtained:And the quantitative analysis of the extraction rate of effective components and theoptimal time varies with the change of the parameters. When the value of extractiontemperature is60℃; the value of particle radius is0.4202mm; the value of ethanolconcentration is70%; the value of liquid material15mL/g. the extraction rate reach themaximum. The extraction temperature is higher, and the smaller particle radius, thegreater the extraction rate, but the value of optimum extraction time is smaller. Theanalysis results show that the extraction temperature and the particle size are the keyinfluencing parameters of the extraction rate and the optimal time. In addition, in adilute solution, the diffusion coefficients formula is:The higher the temperature is, the greater the ethanol concentration, the greater thediffusion coefficients. The extraction temperature is the key parameters influencingdiffusion coefficient③According to the hypothesis and the theoretical analysis of dynamic model, thesingle factor experiment of backflow mixing extract method is designed to extracteffective component of chlorogenic acid from honeysuckle, in order to modify thedynamics model. The percentage of chlorogenic acid from honeysuckle is1.5%underthe soxhlet method. The experiment results: in the extraction temperature group, theextraction temperature is60, the extraction rate of chlorogenic acid from honeysucklereaches the maximum(77.16%); In the particle size group, the particle size is0.4202mm,the extraction rate of chlorogenic acid reaches the maximum(77.31%); In ethanolconcentration group, the ethanol concentration is70%, the extraction rate of chlorogenicacid reaches the maximum(78.04%); In the ratio of solvent to solid, the ratio of solventto solid is15mL/g, the extraction rate of chlorogenic acid reaches themaximum(78.06%). The experimental values of extraction rate of chlorogenic acid from honeysuckle well matched the calculated values of the dynamic model, and the fittingdegree is good. The dynamic model can accurately reflect the real extraction process.The experiments results of is based on model analysis to get the optimal parametersdesign that chlorogenic acid extraction rate (77.16%), is more than the maximum rate ofchlorogenic acid in the literature and increased by6.01%, the dynamic model of naturalproducts has guidance significance to extraction technology practice.