Two-step Circle Assisted By Hydroxyl Group Towardα-branched Primary Amines Directly Using Aqueous Ammonia

This article describes a two steps synthesis of a-branched-chain primary amines using ammonia as starting material. This reaction using solid acid as catalyst, tert-alcohol or benzyl alcohol react with8-hydroxyl-l-naphthalene sulfonic amide, meanwhile,alkylation products can inter-esterificated in the same conditions. Amine generated in inter-esterification could be absorbed by the solid catalyst and it will be released when alkalized, yield of amine can up to15.7%. Choosing732cation exchange resin as catalyst, select the appropriate amount of catalysts and reaction temperature. The results indicated that70℃was an appropriate temperature. When amount of8-hydroxy-1-naphthalene sulfonic amide was0.5mmol, resin for the best dosage is0.4g. This reaction can react in mild conditions, start materials can be recycled, and the catalyst is heterogeneous, easy separation and recovery.Tert-pentanol and α-phenylethylamine were synthesised using the same method.