Study Of Titanocene Perfluorooctanesulfnate / Zinc Restored Diselenides And Its Application

Selenium is an essential trace element for human body.It can be used as anti-cancer,cancer prevention, heart protection prevention and control of cataract,Keshan disease and the Kaschin-Beck disease,delay senility and so on.Selenium also has the same effect as insulin, can regulate blood glucose. It can delay, reduce and prevent the production of diabetic complications. Most diselenides are potential drugs and drug pharmaceuticals for their biological activities,because of Se—Se bond in the structure.At present, there are many methods restored diselenides, but there are a lot of shortages. Titanocene Perfluorooctanesulfnate relatively was stable, while the zinc is a cheap metal and easy to get, therefore, this article designed as Titanocene Perfluorooctanesulfnate/zinc for a system to restore the diselenides and study the reaction with the anhydride, acyl chloride,α-bromo carbonyl compounds and halohydrocarbon, the main research work are as follows:At first, we studied titanocene perfluorooctanesulfnate/zinc system for reducing agent with diselenides, experiment shows that the reduction reaction at room temperature under the protection of nitrogen can be effectively carried out. The response of mild reaction conditions, the product of a single, simple experiment, thus Selenoesters Synthesis provides a simple and effective method. At the same time, the uses of catalyzer and reaction temperature were all discussed, experiment shows that the best condition is at room temperature under the protection of nitrogen and use 5% of catalyst.As follow, we explored the subsequent reduction of the product with theα-bromo carbonyl compounds reacted, the experimental results gave a good result, and obtained a series ofα-selenocarbonyl compounds. The experiment to avoid the use of hard preparation, toxicity, and the stench of the reagents, the experimental operation and post-processing is simple, for theα-Selenocarbonyl Synthesis provides a simple and effective new method.Then we visited the reduction product with the halohydrocarbon compounds , laboratory synthesis of a series of highly efficient selenocarbonyl compounds, the method is avoid direct use of a strong unpleasant smell of benzeneselenol etc, without alkali conditions, which is a better preparation of selenocarbon compounds method.