Synthesis And Spectra Propertie Of New 1,3,4-oxadiazole Compounds With Two-Fluophore-Structures

On the natural organic compounds ,which with biological activities are heterocycliccompounds,especially those containing O,N and S are applicated in many fields such aspesticides,medicines and electron materials.1,3,4-oxadiazole was regarded as very importantfive membered heterocyclic compounds by most of the researchers.This paper contains thesynthesis of furan of 1,3,4-oxadiazole.asymmetric structure of double1,3,4-oxadiazole andhydroxyphenyl benzimidazole of 1,3,4-oxadiazole.On the synthesis of furan of 1,3,4-oxadiazole,The reaction used furfural as the basic rawmaterial by many steps such as Cannizzoro’s reaction,chlorination,hydrazinolysis andcyclization reaction.On the synthesis of asymmetric structure of double1,3,4-oxadiazole, wegot the optimal conditions for their synthesis.The reaction used replaced benzoic acid as thebasic raw material by many steps such as esterification,hydrazinolysis,oxidation,chlorinationand cyclization reaction. This part is the synthesized a series of asymmetric structure ofdouble 1,3,4-oxadiazole compound and the reactive conditions were optimizated,the responsewere moderated and the yield were improved.The optimal reaction time and the dosage ofKMnO4were determined under these conditions.The reaction used phydroxybenzoic acid asthe basic raw material by many steps on the synthesis of hydroxyphenyl benzimidazoleof1,3,4-oxadiazole.This paper was synthesised ten compounds such as ODX1~OXD10 , their structure werecharacterized by1H-NMR, IR.And then this paper has tested these compounds’ opticalpropertie such as UVand fluorescence spectroscopy under the different concentrations.Thesecompounds have good fluorescence properties, this can lay good foundation for the researchof their biological activity.