Synthesis And Properties Study Of Nitrogen Heterocyclic Quinoline Derivatives

Recently, the development of chemosensors for the recognition of physiologically and environmentally important transition metal ions has attracted considerable attention. Among such metal ions, Cu2+is a particularly important divalent cation that plays a vital role in many cellular processes such as those occurring in the human nervous system. Under overloading conditions, Cu2+exhibits toxicity associated with neurodegenerative diseases such as Alzheimer’s disease, infant liver damage, and so on. Among the various detection methods available, colorimetric and fluorescent sensors which were extremely attractive bank on’naked-eye’.Herein we describe our results concerning a sensor based on6-Bromo-4-methyl-phenyl-anthrapyridone (BMPA) derivative, it exhibited a pronounced chromogenic signaling behavior towards Cu2+over other common transition metal ions. A series of6H-indolo-[3,2, b]quinoxaline derivatives were also illustrated on IQ1-IQ9. Their structure was characteristic by means of infrared spectrum, nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.Results revealed that BMPA-1could be used as an efficient Cu2+-selective colorimetric sensor with an excellent selectivity and sensitivity in organic/aqueous media. The detection limit for Cu was determined as2.52×10-8mol/L and the studied other transition metal ions showed negligible interference. Also, color change from yellow to pink could be visually observed after addition of Cu2+in BMPA-1. Through the infrared spectral analysis, these suggests that the1-Cu complex involves Parahelium (N-H) and (C=O) moiety. Not only that, BMPA-1could be used as an efficient AcO--selective sensor which color change from yellow to blue with an excellent selectivity and sensitivity.According to the corresponding formulas that minimum detection limit is3.67×10-8mol/L and complexation constant is1.2×102M-1/2.In the same way IQ2was also studied on the role of metal ions, when the copper exists, indicates that IQ2gradually reduce the fluorescence intensity, As a result of copper is paramagnetic atoms, which IQ2can show a kind of very good fluorescent molecule probe. Not only the BMPA-land IQ2can identify the ion, but also form in small organic molecules gel through the molecular hydrogen bond.