Preparation Technology Of Rhizoma Belamcandae Throat Piece And Quality Standards And Preliminary Stability

Rhizoma Belamcandae throat tablets prescription consisting of:Rhizoma Belamcandae, Sterculia lychnophora, peppermint oil, and the amount of xylitol and other. Rhizoma Belamcandae clearing and detoxifying, Phlegm, the efficacy of the pharynx, is used to heat toxin pyrophlegm blues, sore throat, disease saliva dampness, cough, asthma embolism. Modern pharmacology studies have show that Rhizoma Belamcandae alcohol extracts significantly inhibited the inflammatory and antipyretic effects, Sterculia lychnophora heat lungs, pharynx open sound effects, for Hyperactivity hoarse, dry cough sputum, dry throat pain wait for disease;Peppermint oil to evacuate the wind chill, clear the leader of the pharynx, appear the rash, ShuGan line gas [2’,xylitol sweetness is appropriate, good taste, edible won’t cause glucose levels, diabetes is safe to eat sweeteners.In this experiment, the active ingredient content of Rhizoma Belamcandae and Sterculia lychnophora are indicators, design the orthogonal, preferred the two best extraction process, and its prescription to optimize the design, material selection, to complete the the preparation Rhizoma Belamcandae throat tablet best preparation, in-depth study the quality standards of Rhizoma Belamcandae throat tablet system, designed to develop a new product of a throat clearing.First, the preparation technology research1.the extraction process in Rhizoma Belamcandae----First Single factor and multi-level experiments, with a concentration of60%,70%,80%ethanol to extract the active ingredients of Rhizoma Belamcandae, thus Irisflorentin as the evaluation index, with efficient detection, with liquid chromatography to determine the concentration of Rhizoma Belamcandae the ethanol extract was 70%, and then used L9(34) orthogonal experiment multiples of ethanol solvent extraction, extraction times, extraction time is a factor, inspection Irisflorentin content level and extract yield, were detected by high performance liquid chromatography, to finalize Rhizoma Belamcandae the best extraction technology:six times the dose of70%ethanol extracted three times, each time1.5hours.2.the extraction process of Sterculia lychnophora---of-then orthogonal experiment L9(34), extraction time, extraction temperature, liquid ratio factors, the polysaccharide content and extract yield to examine the extraction process Sterculia lychnophora using UV spectrophotometric detection, the finalization of the Sterculia lychnophora optimum extraction process for the solid to liquid ratio1:30, extraction temperature80℃,extraction time0.5h.3.accessories screening:(1) the choice of the wetting agent, Rhizoma Belamcandae paste powder easy to absorb moisture, through the Single factor and multi-level experiments to a concentration of70%,75%,80%,85%,90%,95%ethanol as a wetting agent granulation optimized concentration of90%ethanol adhesive works best.(2) the amount of xylitol, through the palate selecting each join in per prescriptions of440g xylitol can cover Rhizoma Belamcandae basically do bitterness.(3) of the amount of peppermint oil choice, through the palate in every prescriptions of25ml peppermint oil to join in when the best taste.(4) the choice of the amount of magnesium stearate, through a Single factor and multi-level experiment prescriptions add in3‰4‰,5‰,6‰and7‰magnesium stearate, magnesium stearate optimized to5‰continuous tablets non-stick, tablet better.Second, the quality standard researchIn this study, use thin layer chromatography(TLC) to research Rhizoma Belamcandae, peppermint oil for Qualitative Identification in Rhizoma Belamcandae throat; in Rhizoma Belamcandae Throat Tablets Irisflorentin content using high performance liquid chromatography (HPLC.), The linear relationship, precision, stability, reproducibility, recoveries are in line with the provisions of the pharmacopoeia, and corresponding investigation related project buccal tablet,the indicators are in line with the "Chinese Pharmacopoeia2010edition an appendix under the chip agent regulations. On this basis, the development Rhizoma Belamcandae throat tablet quality standard (draft).Three, preliminary stability studyAccelerated stability inspection stability of Rhizoma Belamcandae throat tablet were investigated, results show that, Rhizoma Belamcandae throat table(?) for6months under accelerated stability conditions, the quality is stable.